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|Title:||Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster|
|Citation:||Russell, F.M., Carapetis, J.R., Satzke, C., Tikoduadua, L., Waqatakirewa, L., Chandra, R., Seduadua, A., Oftadeh, S., Cheung, Y.B., Gilbert, G.L., Mulholland, E.K. (2010-12). Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster. Clinical and Vaccine Immunology 17 (12) : 1970-1976. ScholarBank@NUS Repository. https://doi.org/10.1128/CVI.00117-10|
|Abstract:||This study was conducted to evaluate the effect of a reduced-dose 7-valent pneumococcal conjugate vaccine (PCV) primary series followed by a 23-valent pneumococcal polysaccharide vaccine (23vPPS) booster on nasopharyngeal (NP) pneumococcal carriage. For this purpose, Fijian infants aged 6 weeks were randomized to receive 0, 1, 2, or 3 PCV doses. Within each group, half received 23vPPS at 12 months. NP swabs were taken at 6, 9, 12, and 17 months and were cultured for Streptococcus pneumoniae. Isolates were serotyped by multiplex PCR and a reverse line blot assay. There were no significant differences in PCV vaccine type (VT) carriage between the 3- and 2-dose groups at 12 months. NP VT carriage was significantly higher (P,|
|Source Title:||Clinical and Vaccine Immunology|
|Appears in Collections:||Staff Publications|
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