Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.antiviral.2013.06.002
Title: Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin
Authors: Tay, M.Y.F.
Fraser, J.E.
Chan, W.K.K.
Moreland, N.J.
Rathore, A.P. 
Wang, C.
Vasudevan, S.G. 
Jans, D.A.
Keywords: Dengue
Dengue virus
Flavivirus
Ivermectin
Nonstructural protein-5
Nuclear import
Issue Date: Sep-2013
Citation: Tay, M.Y.F., Fraser, J.E., Chan, W.K.K., Moreland, N.J., Rathore, A.P., Wang, C., Vasudevan, S.G., Jans, D.A. (2013-09). Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin. Antiviral Research 99 (3) : 301-306. ScholarBank@NUS Repository. https://doi.org/10.1016/j.antiviral.2013.06.002
Abstract: Infection by one of the 4 distinct serotypes of dengue virus (DENV) threatens >40% of the world's population, with no efficacious vaccine or antiviral agent currently available. DENV replication through the virus-encoded nonstructural protein (NS) 5 protein occurs in the infected cell cytoplasm, but NS5 from DENV2 has thus far been shown to localize strongly in the nucleus throughout infection. Here we use specific antibodies cross-reactive with NS5 from DENV1-4 to demonstrate nuclear localization of NS5 from all DENV serotypes for the first time in both infected as well as transfected cells, although to differing extents. The small-molecule inhibitor Ivermectin was inhibitory towards both DENV 1 and 2 NS5 interaction with its nuclear transporter importin α/β in vitro, and protected against infection from DENV1-4. Ivermectin thus has potential in the clinical setting as a dengue antiviral. © 2013 Elsevier B.V.
Source Title: Antiviral Research
URI: http://scholarbank.nus.edu.sg/handle/10635/110599
ISSN: 01663542
DOI: 10.1016/j.antiviral.2013.06.002
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