Please use this identifier to cite or link to this item:
|Title:||HINCUTs in cancer: Hypoxia-induced noncoding ultraconserved transcripts|
|Citation:||Ferdin, J., Nishida, N., Wu, X., Nicoloso, M.S., Shah, M.Y., Devlin, C., Ling, H., Shimizu, M., Kumar, K., Cortez, M.A., Ferracin, M., Bi, Y., Yang, D., Czerniak, B., Zhang, W., Schmittgen, T.D., Voorhoeve, M.P., Reginato, M.J., Negrini, M., Davuluri, R.V., Kunej, T., Ivan, M., Calin, G.A. (2013-12). HINCUTs in cancer: Hypoxia-induced noncoding ultraconserved transcripts. Cell Death and Differentiation 20 (12) : 1675-1687. ScholarBank@NUS Repository. https://doi.org/10.1038/cdd.2013.119|
|Abstract:||Recent data have linked hypoxia, a classic feature of the tumor microenvironment, to the function of specific microRNAs (miRNAs); however, whether hypoxia affects other types of noncoding transcripts is currently unknown. Starting from a genome-wide expression profiling, we demonstrate for the first time a functional link between oxygen deprivation and the modulation of long noncoding transcripts from ultraconserved regions, termed transcribed-ultraconserved regions (T-UCRs). Interestingly, several hypoxia-upregulated T-UCRs, henceforth named 'hypoxia-induced noncoding ultraconserved transcripts' (HINCUTs), are also overexpressed in clinical samples from colon cancer patients. We show that these T-UCRs are predominantly nuclear and that the hypoxia-inducible factor (HIF) is at least partly responsible for the induction of several members of this group. One specific HINCUT, uc.475 (or HINCUT-1) is part of a retained intron of the host protein-coding gene, O-linked N-acetylglucosamine transferase, which is overexpressed in epithelial cancer types. Consistent with the hypothesis that T-UCRs have important function in tumor formation, HINCUT-1 supports cell proliferation specifically under hypoxic conditions and may be critical for optimal O-GlcNAcylation of proteins when oxygen tension is limiting. Our data gives a first glimpse of a novel functional hypoxic network comprising protein-coding transcripts and noncoding RNAs (ncRNAs) from the T-UCRs category. © 2013 Macmillan Publishers Limited All rights reserved.|
|Source Title:||Cell Death and Differentiation|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 12, 2018
WEB OF SCIENCETM
checked on Oct 3, 2018
checked on Aug 17, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.