Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijcard.2012.04.004
DC FieldValue
dc.titleFragmented QRS complexes predict right ventricular dysfunction and outflow tract aneurysms in patients with repaired tetralogy of Fallot
dc.contributor.authorShanmugam, N.
dc.contributor.authorYap, J.
dc.contributor.authorTan, R.S.
dc.contributor.authorLe, T.T.
dc.contributor.authorGao, F.
dc.contributor.authorChan, J.X.
dc.contributor.authorChong, D.
dc.contributor.authorHo, K.L.
dc.contributor.authorTan, B.Y.
dc.contributor.authorChing, C.K.
dc.contributor.authorTeo, W.S.
dc.contributor.authorTan, J.L.
dc.contributor.authorLiew, R.
dc.date.accessioned2014-11-26T09:04:09Z
dc.date.available2014-11-26T09:04:09Z
dc.date.issued2013-08-20
dc.identifier.citationShanmugam, N., Yap, J., Tan, R.S., Le, T.T., Gao, F., Chan, J.X., Chong, D., Ho, K.L., Tan, B.Y., Ching, C.K., Teo, W.S., Tan, J.L., Liew, R. (2013-08-20). Fragmented QRS complexes predict right ventricular dysfunction and outflow tract aneurysms in patients with repaired tetralogy of Fallot. International Journal of Cardiology 167 (4) : 1366-1372. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijcard.2012.04.004
dc.identifier.issn01675273
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110537
dc.description.abstractBackground: Fragmented QRS complexes (fQRS) correlate with myocardial scar, and may predict arrhythmias in patients with repaired tetralogy of Fallot (TOF). We investigated the relationship between fQRS in operated TOF patients with right ventricular (RV) dysfunction and RV outflow tract (RVOT) aneurysm. Methods: We studied 56 operated TOF patients with moderate/severe pulmonary regurgitation, referred for cardiac magnetic resonance imaging (MRI) over a 4.5 year period. The presence of fQRS (additional notches in the R/S wave in ≥ 2 contiguous leads on the ECG) was correlated with MRI findings. Results: fQRS was observed in 44 (78.6%) patients. Patients with fQRS had significantly larger RV end diastolic volume index (RVEDVi; 162 ml vs 141 ml, p = 0.028) and RV end systolic volume index (RVESVi; 88 ml vs 70 ml, p = 0.031). Increasing number of leads with fragmentation was independently associated with increasingly lower RV ejection fraction (adjusted co-efficient - 0.97, 95%CI - 1.83 to - 0.12, p = 0.026), greater pulmonary regurgitation fraction (1.65, 0.28 to 3.01, p = 0.019), larger RVEDVi (6.78, 2.00 to 11.56, p = 0.006) and RVESVi (5.41, 1.66 to 9.15, p = 0.005). Anterior fragmentation correlated most significantly with RV dysfunction (p < 0.05). fQRS had no significant association with LV dysfunction. Presence of any fQRS (OR 17.5, 95%CI 2.1-147.8, p = 0.009) and inferior fQRS (OR 9.0, 95%CI 2.7-30.1, p < 0.001) were found to be significant predictors for RVOT aneurysm. Conclusions: The presence of fQRS on the ECG is significantly associated with RV dysfunction and RVOT aneurysms in repaired TOF patients. Increasing burden of fragmentation, especially in the anterior leads, is associated with increasing RV dysfunction. © 2012 Elsevier Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ijcard.2012.04.004
dc.sourceScopus
dc.subjectFragmented QRS
dc.subjectRepaired tetralogy of Fallot
dc.subjectRV dysfunction
dc.subjectRV outflow tract aneurysm
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.ijcard.2012.04.004
dc.description.sourcetitleInternational Journal of Cardiology
dc.description.volume167
dc.description.issue4
dc.description.page1366-1372
dc.description.codenIJCDD
dc.identifier.isiut000323566800057
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.