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Title: Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans
Authors: Sandalova, E.
Laccabue, D.
Boni, C.
Tan, A.T.
Fink, K.
Ooi, E.E.
Chua, R.
Schreve, B.S. 
Ferrari, C.
Bertoletti, A.
Issue Date: Aug-2010
Citation: Sandalova, E., Laccabue, D., Boni, C., Tan, A.T., Fink, K., Ooi, E.E., Chua, R., Schreve, B.S., Ferrari, C., Bertoletti, A. (2010-08). Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans. PLoS Pathogens 6 (8) : 47-48. ScholarBank@NUS Repository.
Abstract: Herpesviruses infect most humans. Their infections can be associated with pathological conditions and significant changes in T cell repertoire but evidences of symbiotic effects of herpesvirus latency have never been demonstrated. We tested the hypothesis that HCMV and EBV-specific CD8 T cells contribute to the heterologous anti-viral immune response. Volume of activated/proliferating virus-specific and total CD8 T cells was evaluated in 50 patients with acute viral infections: 20 with HBV, 12 with Dengue, 12 with Influenza, 3 with Adenovirus infection and 3 with fevers of unknown etiology. Virus-specific (EBV, HCMV, Influenza) pentamer+ and total CD8 T cells were analyzed for activation (CD38/HLA-DR), proliferation (Ki- 7/Bcl- 2low) and cytokine production. We observed that all acute viral infections trigger an expansion of activated/proliferating CD8 T cells, which differs in size depending on the infection but is invariably inflated by CD8 T cells specific for persistent herpesviruses (HCMV/EBV). CD8 T cells specific for other non-related non persistent viral infection (i.e. Influenza) were not activated. IL-15, which is produced during acute viral infections, is the likely contributing mechanism driving the selective activation of herpesvirus specific CD8 T cells. In addition we were able to show that herpesvirus specific CD8 T cells displayed an increased ability to produce the anti-viral cytokine interferon-c during the acute phase of heterologous viral infection. Taken together, these data demonstrated that activated herpesvirus specific CD8 T cells inflate the activated/ proliferating CD8 T cells population present during acute viral infections in human and can contribute to the heterologous anti-viral T cell response. © 2010 Sandalova et al.
Source Title: PLoS Pathogens
ISSN: 15537366
DOI: 10.1371/journal.ppat.1001051
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