Please use this identifier to cite or link to this item: https://doi.org/10.4269/ajtmh.2012.11-0393
Title: Chikungunya and dengue fever among hospitalized febrile patients in Northern Tanzania
Authors: Hertz, J.T.
Munishi, O.M.
Ooi, E.E.
Howe, S.
Lim, W.Y.
Chow, A.
Morrissey, A.B.
Bartlett, J.A.
Onyango, J.J.
Maro, V.P.
Kinabo, G.D.
Saganda, W.
Gubler, D.J. 
Crump, J.A.
Issue Date: Jan-2012
Citation: Hertz, J.T., Munishi, O.M., Ooi, E.E., Howe, S., Lim, W.Y., Chow, A., Morrissey, A.B., Bartlett, J.A., Onyango, J.J., Maro, V.P., Kinabo, G.D., Saganda, W., Gubler, D.J., Crump, J.A. (2012-01). Chikungunya and dengue fever among hospitalized febrile patients in Northern Tanzania. American Journal of Tropical Medicine and Hygiene 86 (1) : 171-177. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.2012.11-0393
Abstract: Consecutive febrile admissions were enrolled at two hospitals in Moshi, Tanzania. Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), and flavivirus infection were defined as a positive polymerase chain reaction (PCR) result. Presumptive acute DENV infection was defined as a positive anti-DENV immunoglobulin M (IgM) enzyme-linked immunsorbent assay (ELISA) result, and prior flavivirus exposure was defined as a positive anti-DENV IgG ELISA result. Among 870 participants, PCR testing was performed on 700 (80.5%). Of these, 55 (7.9%) had confirmed acute CHIKV infection, whereas no participants had confirmed acute DENV or flavivirus infection. Anti- DENV IgM serologic testing was performed for 747 (85.9%) participants, and of these 71 (9.5%) had presumptive acute DENV infection. Anti-DENV IgG serologic testing was performed for 751 (86.3%) participants, and of these 80 (10.7%) had prior flavivirus exposure. CHIKV infection was more common among infants and children than adults and adolescents (odds ratio [OR] 1.9, P = 0.026) and among HIV-infected patients with severe immunosuppression (OR 10.5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
Source Title: American Journal of Tropical Medicine and Hygiene
URI: http://scholarbank.nus.edu.sg/handle/10635/110502
ISSN: 00029637
DOI: 10.4269/ajtmh.2012.11-0393
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

52
checked on Oct 17, 2018

WEB OF SCIENCETM
Citations

47
checked on Oct 1, 2018

Page view(s)

49
checked on Oct 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.