Please use this identifier to cite or link to this item:
Title: Chikungunya and dengue fever among hospitalized febrile patients in Northern Tanzania
Authors: Hertz, J.T.
Munishi, O.M.
Ooi, E.E.
Howe, S.
Lim, W.Y.
Chow, A.
Morrissey, A.B.
Bartlett, J.A.
Onyango, J.J.
Maro, V.P.
Kinabo, G.D.
Saganda, W.
Gubler, D.J. 
Crump, J.A.
Issue Date: Jan-2012
Citation: Hertz, J.T., Munishi, O.M., Ooi, E.E., Howe, S., Lim, W.Y., Chow, A., Morrissey, A.B., Bartlett, J.A., Onyango, J.J., Maro, V.P., Kinabo, G.D., Saganda, W., Gubler, D.J., Crump, J.A. (2012-01). Chikungunya and dengue fever among hospitalized febrile patients in Northern Tanzania. American Journal of Tropical Medicine and Hygiene 86 (1) : 171-177. ScholarBank@NUS Repository.
Abstract: Consecutive febrile admissions were enrolled at two hospitals in Moshi, Tanzania. Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), and flavivirus infection were defined as a positive polymerase chain reaction (PCR) result. Presumptive acute DENV infection was defined as a positive anti-DENV immunoglobulin M (IgM) enzyme-linked immunsorbent assay (ELISA) result, and prior flavivirus exposure was defined as a positive anti-DENV IgG ELISA result. Among 870 participants, PCR testing was performed on 700 (80.5%). Of these, 55 (7.9%) had confirmed acute CHIKV infection, whereas no participants had confirmed acute DENV or flavivirus infection. Anti- DENV IgM serologic testing was performed for 747 (85.9%) participants, and of these 71 (9.5%) had presumptive acute DENV infection. Anti-DENV IgG serologic testing was performed for 751 (86.3%) participants, and of these 80 (10.7%) had prior flavivirus exposure. CHIKV infection was more common among infants and children than adults and adolescents (odds ratio [OR] 1.9, P = 0.026) and among HIV-infected patients with severe immunosuppression (OR 10.5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
Source Title: American Journal of Tropical Medicine and Hygiene
ISSN: 00029637
DOI: 10.4269/ajtmh.2012.11-0393
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 14, 2019


checked on Jan 7, 2019

Page view(s)

checked on Jan 18, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.