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|Title:||Ceramides and glucosylceramides are independent antagonists of insulin signaling|
|Citation:||Chavez, J.A., Siddique, M.M., Wang, S.T., Ching, J., Shayman, J.A., Summers, S.A. (2014-01-10). Ceramides and glucosylceramides are independent antagonists of insulin signaling. Journal of Biological Chemistry 289 (2) : 723-734. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.522847|
|Abstract:||Background: Both ceramides and glucosylceramides have been implicated in the pathogenesis of insulin resistance. Results: These two classes of sphingolipids modulate insulin action but differ by both tissue specificity and mechanism of action. Conclusion: Ceramides and glucosylceramides are independent and separable antagonists of insulin signaling. Significance: These observations will contribute to our understanding of how sphingolipids contribute to obesity-related metabolic diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.|
|Source Title:||Journal of Biological Chemistry|
|Appears in Collections:||Staff Publications|
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