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https://doi.org/10.1074/jbc.M113.522847
Title: | Ceramides and glucosylceramides are independent antagonists of insulin signaling | Authors: | Chavez, J.A. Siddique, M.M. Wang, S.T. Ching, J. Shayman, J.A. Summers, S.A. |
Issue Date: | 10-Jan-2014 | Citation: | Chavez, J.A., Siddique, M.M., Wang, S.T., Ching, J., Shayman, J.A., Summers, S.A. (2014-01-10). Ceramides and glucosylceramides are independent antagonists of insulin signaling. Journal of Biological Chemistry 289 (2) : 723-734. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.522847 | Abstract: | Background: Both ceramides and glucosylceramides have been implicated in the pathogenesis of insulin resistance. Results: These two classes of sphingolipids modulate insulin action but differ by both tissue specificity and mechanism of action. Conclusion: Ceramides and glucosylceramides are independent and separable antagonists of insulin signaling. Significance: These observations will contribute to our understanding of how sphingolipids contribute to obesity-related metabolic diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. | Source Title: | Journal of Biological Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/110500 | ISSN: | 00219258 | DOI: | 10.1074/jbc.M113.522847 |
Appears in Collections: | Staff Publications |
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