Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M113.522847
Title: Ceramides and glucosylceramides are independent antagonists of insulin signaling
Authors: Chavez, J.A.
Siddique, M.M. 
Wang, S.T.
Ching, J.
Shayman, J.A.
Summers, S.A.
Issue Date: 10-Jan-2014
Citation: Chavez, J.A., Siddique, M.M., Wang, S.T., Ching, J., Shayman, J.A., Summers, S.A. (2014-01-10). Ceramides and glucosylceramides are independent antagonists of insulin signaling. Journal of Biological Chemistry 289 (2) : 723-734. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.522847
Abstract: Background: Both ceramides and glucosylceramides have been implicated in the pathogenesis of insulin resistance. Results: These two classes of sphingolipids modulate insulin action but differ by both tissue specificity and mechanism of action. Conclusion: Ceramides and glucosylceramides are independent and separable antagonists of insulin signaling. Significance: These observations will contribute to our understanding of how sphingolipids contribute to obesity-related metabolic diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title: Journal of Biological Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/110500
ISSN: 00219258
DOI: 10.1074/jbc.M113.522847
Appears in Collections:Staff Publications

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