Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0079419
Title: A brain-computer interface based cognitive training system for healthy elderly: A randomized control pilot study for usability and preliminary efficacy
Authors: Lee, T.-S. 
Goh, S.J.A.
Quek, S.Y.
Phillips, R.
Guan, C.
Cheung, Y.B. 
Feng, L.
Teng, S.S.W.
Wang, C.C.
Chin, Z.Y.
Zhang, H.
Ng, T.P.
Lee, J.
Keefe, R.
Krishnan, K.R.R. 
Issue Date: 18-Nov-2013
Citation: Lee, T.-S., Goh, S.J.A., Quek, S.Y., Phillips, R., Guan, C., Cheung, Y.B., Feng, L., Teng, S.S.W., Wang, C.C., Chin, Z.Y., Zhang, H., Ng, T.P., Lee, J., Keefe, R., Krishnan, K.R.R. (2013-11-18). A brain-computer interface based cognitive training system for healthy elderly: A randomized control pilot study for usability and preliminary efficacy. PLoS ONE 8 (11) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0079419
Abstract: Cognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life. Previously, we reported the successful use of a novel brain-computer interface (BCI) training system in improving symptoms of attention deficit hyperactivity disorder. Here, we examine the feasibility of the BCI system with a new game that incorporates memory training in improving memory and attention in a pilot sample of healthy elderly. This study investigates the safety, usability and acceptability of our BCI system to elderly, and obtains an efficacy estimate to warrant a phase III trial. Thirty-one healthy elderly were randomized into intervention (n = 15) and waitlist control arms (n = 16). Intervention consisted of an 8-week training comprising 24 half-hour sessions. A usability and acceptability questionnaire was administered at the end of training. Safety was investigated by querying users about adverse events after every session. Efficacy of the system was measured by the change of total score from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) before and after training. Feedback on the usability and acceptability questionnaire was positive. No adverse events were reported for all participants across all sessions. Though the median difference in the RBANS change scores between arms was not statistically significant, an effect size of 0.6SD was obtained, which reflects potential clinical utility according to Simon's randomized phase II trial design. Pooled data from both arms also showed that the median change in total scores pre and post-training was statistically significant (Mdn = 4.0; p
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/110467
ISSN: 19326203
DOI: 10.1371/journal.pone.0079419
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2013-brain-computer_interface_based_cognitive_training-published.pdf1.65 MBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

24
checked on Oct 16, 2018

WEB OF SCIENCETM
Citations

18
checked on Oct 8, 2018

Page view(s)

78
checked on Sep 28, 2018

Download(s)

23
checked on Sep 28, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.