Please use this identifier to cite or link to this item: https://doi.org/10.1517/17460440903527675
Title: Non-mammalian animal models of Parkinson's disease for drug discovery
Authors: Lim, K.-L. 
Keywords: Caenorhabditis elegans
Drosophila
LRRK2
Neurodegeneration
Parkin
Parkinsons disease
Synuclein
Issue Date: 19-Feb-2010
Citation: Lim, K.-L. (2010-02-19). Non-mammalian animal models of Parkinson's disease for drug discovery. Expert Opinion on Drug Discovery 5 (2) : 165-176. ScholarBank@NUS Repository. https://doi.org/10.1517/17460440903527675
Abstract: Importance of the field: Parkinsons disease (PD) is a prevalent neurodegenerative disease affecting millions of predominantly elderly individuals worldwide. Despite intensive efforts devoted to drug discovery, the disease remains incurable. Compounding this problem is the current lack of a truly representative mammalian model of PD. However, a number of non-mammalian models of PD have been created in recent years that hold tremendous promise to accelerate our understanding of the disease as well as to transform the drug discovery process. Areas covered in this review: This review provides an overview of the various Caenorhabditis elegans and Drosophila genetic models of PD that have been generated to date and discusses the utility of these model systems in the identification of molecules of potential therapeutic value for the PD patient. What the reader will gain: Readers will appreciate the strengths (and limitations) of C. elegans and Drosophila in modeling salient features of the disease as well as their usefulness in uncovering novel genegene interaction and pathways relevant to PD pathogenesis. Readers will also appreciate how technological advancements have allowed the direct evaluation of novel compounds in these living models of PD in a virtually high-throughput manner. Take home message: Non-mammalian models of PD provide a valuable in vivo platform for drug screening. Unlike cell-based systems, these living models with an intact nervous system allow for a more meaningful evaluation of the neuroprotective properties of genetic and chemical modifiers to be conducted. © 2010 Informa UK Ltd ISSN.
Source Title: Expert Opinion on Drug Discovery
URI: http://scholarbank.nus.edu.sg/handle/10635/110443
ISSN: 17460441
DOI: 10.1517/17460440903527675
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

1
checked on Sep 19, 2018

WEB OF SCIENCETM
Citations

1
checked on Sep 5, 2018

Page view(s)

32
checked on Jun 22, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.