Please use this identifier to cite or link to this item: https://doi.org/10.1038/tp.2011.22
Title: Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: A proof of concept
Authors: Kaddurah-Daouk, R.
Boyle, S.H.
Matson, W.
Sharma, S.
Matson, S.
Zhu, H.
Bogdanov, M.B.
Churchill, E.
Krishnan, R.R. 
Rush, A.J. 
Pickering, E.
Delnomdedieu, M.
Keywords: Major depressive disorder
Metabolomics
Placebo
Sertraline
Issue Date: 26-Jul-2011
Citation: Kaddurah-Daouk, R., Boyle, S.H., Matson, W., Sharma, S., Matson, S., Zhu, H., Bogdanov, M.B., Churchill, E., Krishnan, R.R., Rush, A.J., Pickering, E., Delnomdedieu, M. (2011-07-26). Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: A proof of concept. Translational Psychiatry 1 : -. ScholarBank@NUS Repository. https://doi.org/10.1038/tp.2011.22
Abstract: The purpose of this study was to determine whether the baseline metabolic profile (that is, metabotype) of a patient with major depressive disorder (MDD) would define how an individual will respond to treatment. Outpatients with MDD were randomly assigned to sertraline (up to 150 mg per day) (N=43) or placebo (N=46) in a double-blind 4-week trial. Baseline serum samples were profiled using the liquid chromatography electrochemical array; the output was digitized to create a 'digital map' of the entire measurable response for a particular sample. Response was defined as≥50% reduction baseline to week 4 in the 17-item Hamilton Rating Scale for Depression total score. Models were built using the one-out method for cross-validation. Multivariate analyses showed that metabolic profiles partially separated responders and non-responders to sertraline or to placebo. For the sertraline models, the overall correct classification rate was 81% whereas it was 72% for the placebo models. Several pathways were implicated in separation of responders and non-responders on sertraline and on placebo including phenylalanine, tryptophan, purine and tocopherol. Dihydroxyphenylacetic acid, tocopherols and serotonin were common metabolites in separating responders and non-responders to both drug and placebo. Pretreatment metabotypes may predict which depressed patients will respond to acute treatment (4 weeks) with sertraline or placebo. Some pathways were informative for both treatments whereas other pathways were unique in predicting response to either sertraline or placebo. Metabolomics may inform the biochemical basis for the early efficacy of sertraline. © 2011 Macmillan Publishers Limited.
Source Title: Translational Psychiatry
URI: http://scholarbank.nus.edu.sg/handle/10635/110228
ISSN: 21583188
DOI: 10.1038/tp.2011.22
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

63
checked on Jun 16, 2018

WEB OF SCIENCETM
Citations

44
checked on May 30, 2018

Page view(s)

36
checked on Jun 1, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.