Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.vaccine.2010.10.046
Title: Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age
Authors: Russell, F.M.
Carapetis, J.R.
Burton, R.L.
Lin, J.
Licciardi, P.V.
Balloch, A.
Tikoduadua, L.
Waqatakirewa, L.
Cheung, Y.B. 
Tang, M.L.K.
Nahm, M.H.
Mulholland, E.K.
Keywords: Opsonophagocytic activity
Pneumococcal vaccination
Issue Date: 10-Jan-2011
Citation: Russell, F.M., Carapetis, J.R., Burton, R.L., Lin, J., Licciardi, P.V., Balloch, A., Tikoduadua, L., Waqatakirewa, L., Cheung, Y.B., Tang, M.L.K., Nahm, M.H., Mulholland, E.K. (2011-01-10). Opsonophagocytic activity following a reduced dose 7-valent pneumococcal conjugate vaccine infant primary series and 23-valent pneumococcal polysaccharide vaccine at 12 months of age. Vaccine 29 (3) : 535-544. ScholarBank@NUS Repository. https://doi.org/10.1016/j.vaccine.2010.10.046
Abstract: Opsonophagocytic activity (OPA) was measured following reduced infant doses of 7-valent pneumococcal conjugate vaccine (PCV-7) with or without 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months, and subsequent re-exposure to a small dose of pneumococcal polysaccharide antigens (mPPS) at 17 months. Fijian infants were randomized to receive 0, 1, 2, or 3 PCV-7 doses. Half received PPV-23 at 12 months and all received mPPS at 17 months. OPA was performed on up to 14 serotypes. Three and 2 PCV-7 doses resulted in similar OPA for most PCV-7 serotypes up to 9 months and for half of the serotypes at 12 months. A single dose improved OPA compared with the unvaccinated group. PPV-23 significantly improved OPA for all serotypes tested but in general, was associated with diminished responses following re-challenge. © 2010 Elsevier Ltd.
Source Title: Vaccine
URI: http://scholarbank.nus.edu.sg/handle/10635/110199
ISSN: 0264410X
DOI: 10.1016/j.vaccine.2010.10.046
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