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https://doi.org/10.1371/journal.pone.0044206
Title: | MiR-214 Targets β-Catenin Pathway to Suppress Invasion, Stem-Like Traits and Recurrence of Human Hepatocellular Carcinoma | Authors: | Xia, H. Ooi, L.L.P.J. Hui, K.M. |
Issue Date: | 4-Sep-2012 | Citation: | Xia, H., Ooi, L.L.P.J., Hui, K.M. (2012-09-04). MiR-214 Targets β-Catenin Pathway to Suppress Invasion, Stem-Like Traits and Recurrence of Human Hepatocellular Carcinoma. PLoS ONE 7 (9) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0044206 | Abstract: | The down-regulation of miR-214 has previously been observed in human hepatocellular carcinoma (HCC). Here, we demonstrated the down-regulation of miR-214 is associated with cell invasion, stem-like traits and early recurrence of HCC. Firstly, we validated the suppression of miR-214 in human HCC by real-time quantitative RT-PCR (qRT-PCR) in 20 paired tumor and non-tumor liver tissues of HCC patients and 10 histologically normal liver tissues from colorectal cancer patients with liver metastases. Further qRT-PCR analysis of 50 HCC tissues from an independent cohort of HCC patients of whom 29 with early recurrent disease ( | Source Title: | PLoS ONE | URI: | http://scholarbank.nus.edu.sg/handle/10635/110177 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0044206 |
Appears in Collections: | Staff Publications |
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