Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jalz.2010.06.001
Title: Metabolomic changes in autopsy-confirmed Alzheimer's disease
Authors: Kaddurah-Daouk, R.
Rozen, S. 
Matson, W.
Han, X.
Hulette, C.M.
Burke, J.R.
Doraiswamy, P.M.
Welsh-Bohmer, K.A.
Keywords: Alzheimer's
Biomarkers
Diagnosis
Metabolomics
Purine
Staging
Tryptophan
Tyrosine
Issue Date: May-2011
Citation: Kaddurah-Daouk, R., Rozen, S., Matson, W., Han, X., Hulette, C.M., Burke, J.R., Doraiswamy, P.M., Welsh-Bohmer, K.A. (2011-05). Metabolomic changes in autopsy-confirmed Alzheimer's disease. Alzheimer's and Dementia 7 (3) : 309-317. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jalz.2010.06.001
Abstract: Background: Metabolomics, the global science of biochemistry, provides powerful tools to map perturbations in the metabolic network and enables simultaneous quantification of several metabolites to identify metabolic perturbances that might provide insights into disease. Methods: In this pilot study, we took a targeted electrochemistry-based metabolomics approach where liquid chromatography followed by coulometric array detection enables quantification of over 30 metabolites within key neurotransmitter pathways (dopamine and serotonin) and pathways involved in oxidative stress. Results: Using samples from postmortem ventricular cerebrospinal fluid (15 Alzheimer's disease [AD] and 15 nondemented subjects with autopsy-confirmed diagnoses) and by using regression models, correlations, Wilcoxon rank-sum tests, and t-tests we identified alterations in tyrosine, tryptophan, purine, and tocopherol pathways in patients with AD. Reductions in norepinephrine and its related metabolites were also seen, consistent with previously published data. Conclusions: These data support further investigation of metabolomics in larger samples of clinical AD as well as in those with preclinical disease for use as biomarkers. © 2011 The Alzheimer's Association. All rights reserved.
Source Title: Alzheimer's and Dementia
URI: http://scholarbank.nus.edu.sg/handle/10635/110170
ISSN: 15525260
DOI: 10.1016/j.jalz.2010.06.001
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