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Title: MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese
Authors: Li, N.N.
Tan, E.K. 
Chang, X.L.
Mao, X.Y.
Zhao, D.M.
Zhang, J.H.
Liao, Q.
Peng, R.
Keywords: MCCC1/LAMP3
Parkinson's disease
Issue Date: Aug-2013
Citation: Li, N.N., Tan, E.K., Chang, X.L., Mao, X.Y., Zhao, D.M., Zhang, J.H., Liao, Q., Peng, R. (2013-08). MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese. Acta Neurologica Scandinavica 128 (2) : 136-139. ScholarBank@NUS Repository.
Abstract: Background: A recent large-scale replication and heterogeneity study reported the new described GWAS locus (MCCC1/LAMP3 rs11711441) was associated with a reduced risk of Parkinson disease (PD) in Asian and Caucasian populations. Its role is still unknown in a Han Chinese population from mainland China. We genotyped the rs11711441 variant to investigate the association with risk of PD. Methods: Using a case-control methodology, a total of 1428 Han Chinese study subjects were genotyped. We also conducted further stratified analysis according to age at onset and compared the clinical characteristics of GA + AA subjects with GG subjects. Results: In this study, we confirmed that the A allele of MCCC1/LAMP3 (rs11711441) polymorphism reduces the risk to develop sporadic PD (P = 0.043). Additionally, subjects with GA + AA genotypes have a reduced risk compared to those with GG genotype (P = 0.022). The association was seen among the older age group (P = 0.014), but was not significant among the younger age group (P = 0.641). No significant differences were observed in gender, age at onset, and onset symptoms between GA + AA subjects and GG subjects. Conclusion: Our study, the first from Mainland China demonstrates that MCCC1/LAMP3 (rs11711441) is associated with a lower risk of PD. Further studies in additional Chinese populations and other cohorts will be useful. © 2013 John Wiley & Sons A/S.
Source Title: Acta Neurologica Scandinavica
ISSN: 00016314
DOI: 10.1111/ane.12108
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