Please use this identifier to cite or link to this item:
|Title:||MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese|
|Citation:||Li, N.N., Tan, E.K., Chang, X.L., Mao, X.Y., Zhao, D.M., Zhang, J.H., Liao, Q., Peng, R. (2013-08). MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese. Acta Neurologica Scandinavica 128 (2) : 136-139. ScholarBank@NUS Repository. https://doi.org/10.1111/ane.12108|
|Abstract:||Background: A recent large-scale replication and heterogeneity study reported the new described GWAS locus (MCCC1/LAMP3 rs11711441) was associated with a reduced risk of Parkinson disease (PD) in Asian and Caucasian populations. Its role is still unknown in a Han Chinese population from mainland China. We genotyped the rs11711441 variant to investigate the association with risk of PD. Methods: Using a case-control methodology, a total of 1428 Han Chinese study subjects were genotyped. We also conducted further stratified analysis according to age at onset and compared the clinical characteristics of GA + AA subjects with GG subjects. Results: In this study, we confirmed that the A allele of MCCC1/LAMP3 (rs11711441) polymorphism reduces the risk to develop sporadic PD (P = 0.043). Additionally, subjects with GA + AA genotypes have a reduced risk compared to those with GG genotype (P = 0.022). The association was seen among the older age group (P = 0.014), but was not significant among the younger age group (P = 0.641). No significant differences were observed in gender, age at onset, and onset symptoms between GA + AA subjects and GG subjects. Conclusion: Our study, the first from Mainland China demonstrates that MCCC1/LAMP3 (rs11711441) is associated with a lower risk of PD. Further studies in additional Chinese populations and other cohorts will be useful. © 2013 John Wiley & Sons A/S.|
|Source Title:||Acta Neurologica Scandinavica|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 12, 2018
WEB OF SCIENCETM
checked on Sep 4, 2018
checked on Aug 3, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.