Please use this identifier to cite or link to this item: https://doi.org/10.1002/ajmg.b.31124
Title: Genetic analysis of "leucine-rich repeat (LRR) and immunoglobulin (Ig) domain-containing, Nogo receptor-interacting protein-1 (LINGO1)" in two independent Chinese parkinson's disease populations
Authors: Wu, Y.-R.
Tan, E.-K. 
Chen, C.-M.
Kumar, P.M.
Lee-Chen, G.-J.
Chen, S.-T.
Keywords: Disease association
LINGO1
Parkinson's disease
SNP
Issue Date: Jan-2011
Source: Wu, Y.-R., Tan, E.-K., Chen, C.-M., Kumar, P.M., Lee-Chen, G.-J., Chen, S.-T. (2011-01). Genetic analysis of "leucine-rich repeat (LRR) and immunoglobulin (Ig) domain-containing, Nogo receptor-interacting protein-1 (LINGO1)" in two independent Chinese parkinson's disease populations. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 156 (1) : 99-103. ScholarBank@NUS Repository. https://doi.org/10.1002/ajmg.b.31124
Abstract: A large genome-wide association study has shown that the "leucine-rich repeat (LRR) and immunoglobulin (Ig) domain-containing, Nogo receptor-interacting protein-1 (LINGO1) gene" is associated with an increased risk for essential tremor (ET) recently. Given the clinical phenotype overlap between Parkinson's disease (PD) and ET, and LINGO1 had also been demonstrated to play roles in the structural plasticity and integrity of the DA neurons as well as survival of dopaminergic neurons in PD animal models, it has been suggested that the LINGO1 variant could be associated with PD. Here, we report the first analysis of the LINGO1 variant rs9652490 (A>G) in two independent case-control cohorts in ethnic Chinese populations involving a total of 1,305 subjects (649 PD patients and 656 controls) from Taiwan and Singapore. We were unable to demonstrate any significant association between genotype distribution and allele frequency with risk of PD in each case-control study and in the pooled analysis. Further meta-analysis including all published data and ours failed to demonstrate any modulatory role of rs9652490 GG genotype or G allele. LINGO1 variant rs9652490 (A>G) is unlikely to play a major role in PD in our Chinese populations. © 2010 Wiley-Liss, Inc.
Source Title: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/110095
ISSN: 15524841
DOI: 10.1002/ajmg.b.31124
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

10
checked on Feb 14, 2018

WEB OF SCIENCETM
Citations

10
checked on Jan 16, 2018

Page view(s)

28
checked on Feb 18, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.