Please use this identifier to cite or link to this item:
Title: Depression treatment in patients with general medical conditions: Results from the CO-MED trial
Authors: Morris, D.W.
Budhwar, N.
Husain, M.
Wisniewski, S.R.
Kurian, B.T.
Luther, J.F.
Kerber, K.
Rush, A.J. 
Trivedi, M.H.
Keywords: Antidepressant
General medical condition
Mental health
Mood disorder
Practicebased research
Primary care
Issue Date: Jan-2012
Source: Morris, D.W., Budhwar, N., Husain, M., Wisniewski, S.R., Kurian, B.T., Luther, J.F., Kerber, K., Rush, A.J., Trivedi, M.H. (2012-01). Depression treatment in patients with general medical conditions: Results from the CO-MED trial. Annals of Family Medicine 10 (1) : 23-33. ScholarBank@NUS Repository.
Abstract: PURPOSE We studied the effect of 3 antidepressant treatments on outcomes (depressive severity, medication tolerability, and psychosocial functioning) in depressed patients having comorbid general medical conditions in the Combining Medications to Enhance Depression Outcomes (CO-MED) trial. METHODS Adult outpatients who had chronic and/or recurrent major depressive disorder (MDD) with and without general medical conditions were randomly assigned in 1:1:1 ratio to 28 weeks of single-blind, placebo-controlled antidepressant treatment with (1) escitalopram plus placebo, (2) bupropion-SR plus escitalopram, or (3) venlafaxine-XR plus mirtazapine. At weeks 12 and 28, we compared response and tolerability between participants with 0, 1, 2, and 3 or more general medical conditions. RESULTS Of the 665 evaluable patients, 49.5% reported having no treated general medical conditions, 23.8% reported having 1, 14.8% reported having 2, and 11.9% reported having at least 3. We found only minimal differences in antidepressant treatment response between these groups having different numbers of conditions; patients with 3 or more conditions reported higher rates of impairment in social and occupational functioning at week 12 but not at week 28. Additionally, we found no signifi cant differences between the 3 antidepressant treatments across these groups. CONCLUSIONS Patients with general medical conditions can be safely and effectively treated for MDD with antidepressants with no additional adverse effect or tolerability burden relative to their counterparts without such conditions. Combination therapy is not associated with an increased treatment response beyond that found with traditional monotherapy in patients with MDD, regardless of the presence and number of general medical conditions.
Source Title: Annals of Family Medicine
ISSN: 15441709
DOI: 10.1370/afm.1316
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Mar 8, 2018


checked on Feb 13, 2018

Page view(s)

checked on Mar 12, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.