Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cct.2013.03.012
Title: Conducting randomised controlled trials across countries with disparate levels of socio-economic development: The experience of the Asia-Pacific Hepatocellular Carcinoma Trials Group
Authors: Kong, N.H.Y.
Chow, P.K.H. 
Keywords: Clinical trials
Hepatocellular carcinoma
Randomised controlled trials
Issue Date: Nov-2013
Source: Kong, N.H.Y., Chow, P.K.H. (2013-11). Conducting randomised controlled trials across countries with disparate levels of socio-economic development: The experience of the Asia-Pacific Hepatocellular Carcinoma Trials Group. Contemporary Clinical Trials 36 (2) : 682-686. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cct.2013.03.012
Abstract: Hepatocellular carcinoma (HCC), which constitutes over 85-90% of all primary liver cancers, is the most predominant type of liver cancer, and the third leading cause of cancer related deaths in the world. While the Asia-Pacific is a highly heterogeneous region in geography, ethnicity and in the level of socio-economic development, the main burden of HCC falls in this region and there are compelling reasons and advantages to conduct definitive clinical trials in HCC where it is endemic. The Asia-Pacific Hepatocellular Carcinoma (AHCC) Trials Group was established in 1997 and has faced and overcome challenges that are inherent in conducting clinical trials in a disparate region. Clinical trial infrastructure is rudimentary at many sites and requires significant effort to be expended on training and monitoring to ensure production of definitive data. The benefits of industrial support of Investigator-Initiated Trials are discussed in the context of the Asia-Pacific. The positive experience of the AHCC trials group would be valuable to any collaborative trials in countries with disparate levels of socio-economic development. © 2013 Elsevier Inc.
Source Title: Contemporary Clinical Trials
URI: http://scholarbank.nus.edu.sg/handle/10635/109982
ISSN: 15517144
DOI: 10.1016/j.cct.2013.03.012
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