Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0039575
Title: Comparability of results from pair and classical model formulations for different sexually transmitted infections
Authors: Ong, J.B.S.
Fu, X.
Lee, G.K.K.
Chen, M.I.-C. 
Issue Date: 27-Jun-2012
Source: Ong, J.B.S., Fu, X., Lee, G.K.K., Chen, M.I.-C. (2012-06-27). Comparability of results from pair and classical model formulations for different sexually transmitted infections. PLoS ONE 7 (6) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0039575
Abstract: The "classical model" for sexually transmitted infections treats partnerships as instantaneous events summarized by partner change rates, while individual-based and pair models explicitly account for time within partnerships and gaps between partnerships. We compared predictions from the classical and pair models over a range of partnership and gap combinations. While the former predicted similar or marginally higher prevalence at the shortest partnership lengths, the latter predicted self-sustaining transmission for gonorrhoea (GC) and Chlamydia (CT) over much broader partnership and gap combinations. Predictions on the critical level of condom use (Cc) required to prevent transmission also differed substantially when using the same parameters. When calibrated to give the same disease prevalence as the pair model by adjusting the infectious duration for GC and CT, and by adjusting transmission probabilities for HIV, the classical model then predicted much higher Cc values for GC and CT, while Cc predictions for HIV were fairly close. In conclusion, the two approaches give different predictions over potentially important combinations of partnership and gap lengths. Assuming that it is more correct to explicitly model partnerships and gaps, then pair or individual-based models may be needed for GC and CT since model calibration does not resolve the differences. © 2012 Ong et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/109973
ISSN: 19326203
DOI: 10.1371/journal.pone.0039575
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2012-Comparability_of_Results_from_Pair -published.PDF1.08 MBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

2
checked on Feb 19, 2018

WEB OF SCIENCETM
Citations

2
checked on Feb 19, 2018

Page view(s)

27
checked on Feb 18, 2018

Download(s)

3
checked on Feb 18, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.