Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jgar.2013.10.002
Title: Changing molecular epidemiology and high rates of mupirocin resistance among meticillin-resistant Staphylococcus aureus in Singaporean hospitals
Authors: Hon, P.Y.
Koh, T.H. 
Tan, T.Y.
Krishnan, P.
Leong, J.W.-Y.
Jureen, R.
Chan, J.
Tee, N.W.-S.
Murugesh, J.
Chan, K.S.
Hsu, L.Y.
Keywords: Epidemiology
High-level mupirocin resistance
ileS-2
Meticillin-resistant Staphylococcus aureus
Issue Date: 2014
Citation: Hon, P.Y., Koh, T.H., Tan, T.Y., Krishnan, P., Leong, J.W.-Y., Jureen, R., Chan, J., Tee, N.W.-S., Murugesh, J., Chan, K.S., Hsu, L.Y. (2014). Changing molecular epidemiology and high rates of mupirocin resistance among meticillin-resistant Staphylococcus aureus in Singaporean hospitals. Journal of Global Antimicrobial Resistance 2 (1) : 53-55. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jgar.2013.10.002
Abstract: A prospective cross-sectional study was performed to determine the continuing shift in the molecular epidemiology of meticillin-resistant Staphylococcus aureus (MRSA) in Singapore. In total, 666 MRSA isolates from screening cultures performed between 7 and 20 January 2013 were obtained from all seven public sector hospitals in Singapore and were subjected to molecular typing using multilocus variable-number tandem-repeat fingerprinting with confirmatory multilocus sequencing typing for clustered isolates. Isolates were also tested for the presence of the orfX-ACME insert and the high-level mupirocin resistance gene ileS-2. The major circulating clones in Singaporean hospitals were ST22 (63.2%), ST45 (18.9%) and ST239 (10.7%). The orfX-ACME insert was only found in ST239 isolates (31/71, 43.7%), but ileS-2 was found in 207 (31.1%) of the MRSA isolates, varying between 10.0% and 47.8% among the hospitals. In conclusion, the molecular epidemiology of MRSA in Singaporean hospitals has continued to change, with ST45 now replacing ST239 in addition to the ongoing replacement of the latter by ST22. Although a greater proportion of ST239 isolates carry the orfX-ACME insert, the actual clinical impact may be marginal as ST239 MRSA continues to decline. Finally, high-level mupirocin resistance rates are remarkably high in local healthcare-associated MRSA, with implications for MRSA decolonisation and infection prevention. Further surveillance is required to monitor the changing epidemiological trends. © 2013 International Society for Chemotherapy of Infection and Cancer.
Source Title: Journal of Global Antimicrobial Resistance
URI: http://scholarbank.nus.edu.sg/handle/10635/109960
ISSN: 22137173
DOI: 10.1016/j.jgar.2013.10.002
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