Please use this identifier to cite or link to this item:
|Title:||Association of HLA locus variant in parkinson's disease|
|Citation:||Zhao, Y., Gopalai, A.A., Ahmad-Annuar, A., Teng, E.W.L., Prakash, K.M., Tan, L.C.S., Au, W.-L., Li, H.-H., Lim, S.-Y., Lim, S.K., Chong, Y.B., Tan, L.P., Ibrahim, N.M., Tan, E.-K. (2013-11). Association of HLA locus variant in parkinson's disease. Clinical Genetics 84 (5) : 501-504. ScholarBank@NUS Repository. https://doi.org/10.1111/cge.12024|
|Abstract:||A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95% confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD. © 2012 John Wiley & Sons A/S.|
|Source Title:||Clinical Genetics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 21, 2018
WEB OF SCIENCETM
checked on Sep 11, 2018
checked on Aug 3, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.