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Title: Association of HLA locus variant in parkinson's disease
Authors: Zhao, Y.
Gopalai, A.A.
Ahmad-Annuar, A.
Teng, E.W.L.
Prakash, K.M.
Tan, L.C.S.
Au, W.-L.
Li, H.-H.
Lim, S.-Y.
Lim, S.K.
Chong, Y.B.
Tan, L.P.
Ibrahim, N.M.
Tan, E.-K. 
Keywords: Chinese
Parkinson's disease
Issue Date: Nov-2013
Citation: Zhao, Y., Gopalai, A.A., Ahmad-Annuar, A., Teng, E.W.L., Prakash, K.M., Tan, L.C.S., Au, W.-L., Li, H.-H., Lim, S.-Y., Lim, S.K., Chong, Y.B., Tan, L.P., Ibrahim, N.M., Tan, E.-K. (2013-11). Association of HLA locus variant in parkinson's disease. Clinical Genetics 84 (5) : 501-504. ScholarBank@NUS Repository.
Abstract: A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95% confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD. © 2012 John Wiley & Sons A/S.
Source Title: Clinical Genetics
ISSN: 00099163
DOI: 10.1111/cge.12024
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