Please use this identifier to cite or link to this item:
|Title:||Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese|
|Authors:||Tan, E.K. |
|Citation:||Tan, E.K., Lu, C.S., Peng, R., Teo, Y.Y., Wu-Chou, Y.H., Chen, R.S., Weng, Y.H., Chen, C.M., Fung, H.C., Tan, L.C., Zhang, Z.J., An, X.K., Lee-Chen, G.J., Lee, M.C., Fook-Chong, S., Burgunder, J.M., Wu, R.M., Wu, Y.R. (2010-12). Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. Neurobiology of Aging 31 (12) : 2194-2196. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2008.11.008|
|Abstract:||The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD. © 2008 Elsevier Inc.|
|Source Title:||Neurobiology of Aging|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 20, 2019
WEB OF SCIENCETM
checked on Mar 11, 2019
checked on Feb 1, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.