Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00213-009-1625-1
Title: Alterations in tryptophan and purine metabolism in cocaine addiction: A metabolomic study
Authors: Patkar, A.A.
Rozen, S. 
Mannelli, P.
Matson, W.
Pae, C.-U.
Krishnan, K.R. 
Kaddurah-Daouk, R.
Keywords: Addiction
Cocaine
Metabolomics
Methylation
N methyl serotonin
Purine
Tryptophan
Issue Date: 2009
Citation: Patkar, A.A., Rozen, S., Mannelli, P., Matson, W., Pae, C.-U., Krishnan, K.R., Kaddurah-Daouk, R. (2009). Alterations in tryptophan and purine metabolism in cocaine addiction: A metabolomic study. Psychopharmacology 206 (3) : 479-489. ScholarBank@NUS Repository. https://doi.org/10.1007/s00213-009-1625-1
Abstract: Background: Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets. Objective: We examined the differences in metabolites related to the tyrosine, tryptophan, purine, and oxidative stress pathways between cocaine-dependent subjects and healthy controls. Several of these metabolites serve as biological indices underlying the mechanisms of reinforcement, toxicity, and oxidative stress. Methods: Metabolomic analysis was performed in 18 DSM-IV-diagnosed cocaine-dependent individuals with at least 2 weeks of abstinence and ten drug-free controls. Plasma concentrations of 37 known metabolites were analyzed and compared using a liquid chromatography electrochemical array platform. Multivariate analyses were used to study the relationship between severity of drug use [Addiction Severity Index (ASI) scores] and biological measures. Results: Cocaine subjects showed significantly higher levels of n-methylserotonin (p< 0.0017) and guanine (p
Source Title: Psychopharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/109919
ISSN: 00333158
DOI: 10.1007/s00213-009-1625-1
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