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|Title:||Alterations in tryptophan and purine metabolism in cocaine addiction: A metabolomic study|
N methyl serotonin
|Citation:||Patkar, A.A., Rozen, S., Mannelli, P., Matson, W., Pae, C.-U., Krishnan, K.R., Kaddurah-Daouk, R. (2009). Alterations in tryptophan and purine metabolism in cocaine addiction: A metabolomic study. Psychopharmacology 206 (3) : 479-489. ScholarBank@NUS Repository. https://doi.org/10.1007/s00213-009-1625-1|
|Abstract:||Background: Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets. Objective: We examined the differences in metabolites related to the tyrosine, tryptophan, purine, and oxidative stress pathways between cocaine-dependent subjects and healthy controls. Several of these metabolites serve as biological indices underlying the mechanisms of reinforcement, toxicity, and oxidative stress. Methods: Metabolomic analysis was performed in 18 DSM-IV-diagnosed cocaine-dependent individuals with at least 2 weeks of abstinence and ten drug-free controls. Plasma concentrations of 37 known metabolites were analyzed and compared using a liquid chromatography electrochemical array platform. Multivariate analyses were used to study the relationship between severity of drug use [Addiction Severity Index (ASI) scores] and biological measures. Results: Cocaine subjects showed significantly higher levels of n-methylserotonin (p< 0.0017) and guanine (p|
|Appears in Collections:||Staff Publications|
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