Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.pscychresns.2012.03.007
Title: AGTR1 gene variation: Association with depression and frontotemporal morphology
Authors: Taylor, W.D.
Benjamin, S.
McQuoid, D.R.
Payne, M.E.
Krishnan, R.R. 
MacFall, J.R.
Ashley-Koch, A.
Keywords: Amygdala
Genetic polymorphisms
Geriatrics
Hippocampus
MRI
Prefrontal cortex
Renin-angiotensin system
Issue Date: 31-May-2012
Citation: Taylor, W.D., Benjamin, S., McQuoid, D.R., Payne, M.E., Krishnan, R.R., MacFall, J.R., Ashley-Koch, A. (2012-05-31). AGTR1 gene variation: Association with depression and frontotemporal morphology. Psychiatry Research - Neuroimaging 202 (2) : 104-109. ScholarBank@NUS Repository. https://doi.org/10.1016/j.pscychresns.2012.03.007
Abstract: The renin-angiotensin system (RAS) is implicated in the response to physiological and psychosocial stressors, but its role in stress-related psychiatric disorders is poorly understood. We examined if variation in AGTR1, the gene coding for the type 1 angiotensin II receptor (AT1R), is associated with a diagnosis of depression and differences in white matter hyperintensities and frontotemporal brain volumes. Participants comprised 257 depressed and 116 nondepressed elderly Caucasian subjects who completed clinical assessments and provided blood samples for genotyping. We used a haplotype-tagging single nucleotide polymorphism (htSNP) analysis to test for variation in AGTR1. For measurement of hyperintense lesions, 1.5 Tesla magnetic resonance imaging (MRI) data were available on 33 subjects. For measurements of the hippocampus and dorsolateral prefrontal cortex (dlPFC), 3 Tesla MRI data were available on 70 subjects. Two htSNPs exhibited statistically significant frequency differences between diagnostic cohorts: rs10935724 and rs12721331. Although hyperintense lesion volume did not significantly differ by any htSNP, dlPFC and hippocampus volume differed significantly for several htSNPs. Intriguingly, for those htSNPs differing significantly for both dlPFC and hippocampus volume, the variant associated with smaller dlPFC volume was associated with larger hippocampal volume. This supports the idea that genetic variation in AGTR1 is associated with depression and differences in frontotemporal morphology. © 2012 Elsevier Ireland Ltd.
Source Title: Psychiatry Research - Neuroimaging
URI: http://scholarbank.nus.edu.sg/handle/10635/109917
ISSN: 09254927
DOI: 10.1016/j.pscychresns.2012.03.007
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

16
checked on Dec 10, 2018

WEB OF SCIENCETM
Citations

14
checked on Dec 10, 2018

Page view(s)

81
checked on Dec 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.