Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11605-009-0828-4
Title: A single-institution experience with eight CD117-positive primary extragastrointestinal stromal tumors: Critical appraisal and a comparison with their gastrointestinal counterparts
Authors: Goh, B.K.P.
Chow, P.K.H. 
Kesavan, S.M.
Yap, W.-M.
Chung, Y.-F.A.
Wong, W.-K.
Keywords: EGIST
Extragastrointestinal stromal tumor
Gastrointestinal stromal tumor
GIST
Mesentery
Omentum
Issue Date: Jun-2009
Citation: Goh, B.K.P., Chow, P.K.H., Kesavan, S.M., Yap, W.-M., Chung, Y.-F.A., Wong, W.-K. (2009-06). A single-institution experience with eight CD117-positive primary extragastrointestinal stromal tumors: Critical appraisal and a comparison with their gastrointestinal counterparts. Journal of Gastrointestinal Surgery 13 (6) : 1094-1098. ScholarBank@NUS Repository. https://doi.org/10.1007/s11605-009-0828-4
Abstract: Introduction: Gastrointestinal stromal tumors (GISTs) arising from outside the gut wall also termed extragastrointestinal stromal tumors (EGISTs) are reported to be rare. Presently, their pathogenesis remains controversial, and recently, it has been proposed that EGISTs may be the result of extensive extramural growth of GISTs which lose contact with the gut wall. This study presents a single-institution experience with eight EGISTs and compares their clinicopathological features with mural GISTs in order to determine further insight to their possible origin. Methods: Between 1997 and 2008, 156 patients with pathologically proven CD117-positive primary GISTs were retrospectively reviewed. Eight tumors were identified as EGISTs, 104 were gastric GISTs, and 44 were small-bowel GISTs. Mural GISTs were classified as extramural or intra/transmural according to their gross pattern of growth. Results: There were five male and three female patients with a median age of 58 years (range, 42-81 years). All patients were symptomatic, and the tumors were located in the greater omentum (n∈=∈2), lesser sac (n∈=∈2), lesser omentum, retroperitoneum, small-bowel mesentery, and pancreas. The median tumor size was 140 mm (range, 55 to 220 mm). Seven of eight EGISTs were found to be in close association to the adjacent gut wall. Pathological examination demonstrated that two tumors demonstrated focal involvement of the muscularis propria of the adjacent gut wall. Four tumors demonstrated tumor abutting or adherent to the serosa but no muscle involvement and one tumor was separated from the serosa. Comparison between the clinicopathological features of EGISTs with extramural GISTs and intra/transmural GISTs demonstrated that EGISTs were significantly larger [140 range (55-220) mm vs 80 (5-260) mm vs 50 (15-190) mm, P∈=∈0.049, P∈
Source Title: Journal of Gastrointestinal Surgery
URI: http://scholarbank.nus.edu.sg/handle/10635/109903
ISSN: 1091255X
DOI: 10.1007/s11605-009-0828-4
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