Please use this identifier to cite or link to this item: https://doi.org/10.3109/15419061.2010.549976
Title: Unique intracellular trafficking processes associated with neural cell adhesion molecule and its intracellular signaling
Authors: Chen, Y.
Tang, B.L. 
Keywords: fi broblast growth factor receptor (FGFR)
neural cell adhesion molecule (NCAM)
protein traffi cking
signaling
Issue Date: Aug-2011
Citation: Chen, Y., Tang, B.L. (2011-08). Unique intracellular trafficking processes associated with neural cell adhesion molecule and its intracellular signaling. Cell Communication and Adhesion 17 (4-6) : 69-74. ScholarBank@NUS Repository. https://doi.org/10.3109/15419061.2010.549976
Abstract: Homophilic binding of the neural cell adhesion molecule (NCAM) results in intracellular signaling, which also involves heterophilic engagement of coreceptors such as the fibroblast growth factor receptor (FGFR) and receptor protein tyrosine phosphatase-αα (RPTPαα) . NCAM's own cellular dynamic itinerary includes endocytosis and recycling to the plasma membrane. Recent works suggest that NCAM could influence the trafficking of other receptor molecules that it associates with, particularly the FGFR. Furthermore, it was demonstrated that NCAM could undergo proteolytic processing upon activation. A processed fragment of NCAM, together with an N-terminal fragment of focal adhesion kinase (FAK), is translocated into the nucleus. Here, the authors discuss these rather unique (though not without precedence and analogues) receptor trafficking activities that are associated with NCAM and NCAM signaling. © 2011 Informa Healthcare USA, Inc.
Source Title: Cell Communication and Adhesion
URI: http://scholarbank.nus.edu.sg/handle/10635/109880
ISSN: 15419061
DOI: 10.3109/15419061.2010.549976
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