Please use this identifier to cite or link to this item: https://doi.org/10.4028/www.scientific.net/AMR.749.304
Title: Enantiomeric separation of 1-phenyl-1-propanol using calix [4]arene-capped β-cyclodextrin-bonded silica particles as chiral stationary phase in capillary electrochromatography
Authors: Zhao, J.
Li, J.
Yong, E.L.
Gong, Y.H. 
Keywords: Capillary Electrochromatography
Chiral Separation
Chiral Stationary Phase
Issue Date: 2013
Citation: Zhao, J., Li, J., Yong, E.L., Gong, Y.H. (2013). Enantiomeric separation of 1-phenyl-1-propanol using calix [4]arene-capped β-cyclodextrin-bonded silica particles as chiral stationary phase in capillary electrochromatography. Advanced Materials Research 749 : 304-308. ScholarBank@NUS Repository. https://doi.org/10.4028/www.scientific.net/AMR.749.304
Abstract: A new type of calix [4] arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy) propylsilyl-appended silica particles (C4CD-HPS) has been successfully used as chiral stationary phase (CSP) in capillary electrochromatography (CEC) for separation of enantiomers of 1-phenyl-1-propanol for the first time. C4CD-HPS contains a chiral selector with two recognition sites: calix [4]arene and β-cyclodextrin. Due to the cooperative functioning of the calix [4]arene and β-cyclodextrin, C4CD-HPS has exhibited excellent enantioselectivity for the enantiomers of 1-phenyl-1-propanol. After the multiple phenolic hydroxyl groups in the calix [4]arene moieties are ionized in the running buffer, the bonded stationary phase C4CD-HPS becomes negatively-charged to provide high electroosmotic flow (EOF) in CEC. Fast and high-resolution separation for enantiomers of 1-phenyl-1-propanol has been easily achieved on C4CD-HPS. This new type of chiral stationary phase has exhibited great potential for fast enantiomeric separations in CEC. © (2013) Trans Tech Publications, Switzerland.
Source Title: Advanced Materials Research
URI: http://scholarbank.nus.edu.sg/handle/10635/109750
ISBN: 9783037857557
ISSN: 10226680
DOI: 10.4028/www.scientific.net/AMR.749.304
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