Please use this identifier to cite or link to this item:
Title: Urocortin inhibits mesenteric arterial remodeling in spontaneously hypertensive rats
Authors: Chen, J.
Tao, J.
Zhang, R.
Xu, Y.
Soong, T. 
Li, S.
Keywords: Arterial remodeling
Spontaneously hypertensive rats
Issue Date: Jun-2009
Citation: Chen, J., Tao, J., Zhang, R., Xu, Y., Soong, T., Li, S. (2009-06). Urocortin inhibits mesenteric arterial remodeling in spontaneously hypertensive rats. Peptides 30 (6) : 1117-1123. ScholarBank@NUS Repository.
Abstract: Urocortin (UCN), a newly isolated corticotrophin-releasing factor (CRF) related peptide, has been found to have potent cardiovascular protective effects. This study aimed to investigate the long-term effects of UCN on arterial remodeling and related functional alterations. UCN (7 μg/kg/d) was administered to spontaneously hypertensive rats (SHR) for 8 weeks. Systolic blood pressure (SBP) was measured weekly. Functional studies were performed on isolated mesenteric arterial segments. Also, by light microscope and electron microscope, the morphology of mesenteric arteries was examined. Our results showed that mean SBP in UCN-treated SHRs was about 40 mmHg lower than that of the control SHR group, and was similar to that of the enalapril-treated group. In the mesenteric arterial segments pre-contracted with norepinephrine (0.001-10 μM), the maximal relaxation rate induced by acetylcholine (10 μM) in UCN-treated group (about 93.3%) was higher than that in SHR control group (about 40.0%) (n = 6, P < 0.01). Furthermore examination under light microscope showed that UCN (3.5 μg/kg/d) treatment significantly reduced media thickness, media/lumen ratio, resulting in larger lumen diameter while analysis of transmission electron microscopic findings revealed that chromatin, internal elastic lamina and densely packed mitochondria displayed a close-to-normal distribution after UCN treatment. These results suggested that long-term UCN treatment not only had hypotensive effects but may also inhibited development of vascular remodeling in mesenteric arteries in SHR. © 2009 Elsevier Inc. All rights reserved.
Source Title: Peptides
ISSN: 01969781
DOI: 10.1016/j.peptides.2009.02.014
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Dec 12, 2018


checked on Dec 12, 2018

Page view(s)

checked on Dec 14, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.