Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2474-13-255
Title: The relationship between retinal vessel calibre and knee cartilage and BMLs
Authors: Davies-Tuck, M.L.
Kawasaki, R.
Wluka, A.E.
Wong, T.Y. 
Hodgson, L.
English, D.R.
Giles, G.G.
Cicuttini, F.
Issue Date: 2012
Source: Davies-Tuck, M.L., Kawasaki, R., Wluka, A.E., Wong, T.Y., Hodgson, L., English, D.R., Giles, G.G., Cicuttini, F. (2012). The relationship between retinal vessel calibre and knee cartilage and BMLs. BMC Musculoskeletal Disorders 13 : -. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2474-13-255
Abstract: Background: Whether the increase in vascular disease prevalence and mortality in OA populations is a result of co-occurrence of cardiovascular disease and OA, which are both common in the older population, is due to OA treatments or to the common association with reduced physical activity and/or obesity is unclear. One way to explore this non-invasively is to examine the cross-sectional relationship between changes in retinal microvasculature, which have been shown to be markers of generalized vascular pathology, and knee structural changes in an asymptomatic community-based population. Methods. A community sample of 289 (61% women) aged 50-79 years with no knee symptoms underwent magnetic resonance imaging (MRI) of their dominant knee in 2003. Cartilage volume and bone marrow lesions (BMLs) were determined. All subjects also had retinal photographs taken from which retinal arteriolar and venular diameters were determined and summarized as the central retinal arteriolar equivalent (CRAE) and the central retinal venular equivalent (CRVE). Results: Retinal venular diameter was significantly wider in subjects with a BML compared with subjects without a BML (mean (SD) 214.2 (2.8) μm versus 207.5 (1.1) μm respectively independent of age, gender and BMI. A trend for decreased medial tibial cartilage with increasing CRAE was also observed (regression coefficient -2.70 μl, 95%CI-5.74, 0.5, p=0.08). Conclusion: These findings suggest that vascular pathology, indicative of inflammatory processes, is associated with early structural knee changes. The role of micro-vascular changes in the pathogenesis of OA warrants further investigation. © 2012 Davies-Tuck et al.; licensee BioMed Central Ltd.
Source Title: BMC Musculoskeletal Disorders
URI: http://scholarbank.nus.edu.sg/handle/10635/109704
ISSN: 14712474
DOI: 10.1186/1471-2474-13-255
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2012-relationship_between_retinal_vessel_calibre-published.pdf303.07 kBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

7
checked on Jan 17, 2018

WEB OF SCIENCETM
Citations

6
checked on Jan 8, 2018

Page view(s)

36
checked on Jan 15, 2018

Download(s)

3
checked on Jan 15, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.