Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0050224
Title: The Association of Systemic Microvascular Changes with Lung Function and Lung Density: A Cross-Sectional Study
Authors: Harris, B.
Klein, R.
Jerosch-Herold, M.
Hoffman, E.A.
Ahmed, F.S.
Jacobs Jr., D.R.
Klein, B.E.K.
Wong, T.Y. 
Lima, J.A.C.
Cotch, M.F.
Barr, R.G.
Issue Date: 20-Dec-2012
Citation: Harris, B., Klein, R., Jerosch-Herold, M., Hoffman, E.A., Ahmed, F.S., Jacobs Jr., D.R., Klein, B.E.K., Wong, T.Y., Lima, J.A.C., Cotch, M.F., Barr, R.G. (2012-12-20). The Association of Systemic Microvascular Changes with Lung Function and Lung Density: A Cross-Sectional Study. PLoS ONE 7 (12) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0050224
Abstract: Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45-84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV1) (P
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/109686
ISSN: 19326203
DOI: 10.1371/journal.pone.0050224
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