Please use this identifier to cite or link to this item: https://doi.org/10.1001/jamainternmed.2013.1583
Title: The association of aspirin use with age-related macular degeneration
Authors: Liew, G.
Mitchell, P.
Wong, T.Y. 
Rochtchina, E.
Wang, J.J.
Issue Date: 25-Feb-2013
Source: Liew, G., Mitchell, P., Wong, T.Y., Rochtchina, E., Wang, J.J. (2013-02-25). The association of aspirin use with age-related macular degeneration. JAMA Internal Medicine 173 (4) : 258-264. ScholarBank@NUS Repository. https://doi.org/10.1001/jamainternmed.2013.1583
Abstract: Objective: To determine whether regular aspirin use is associated with a higher risk for developing agerelated macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort. Methods: A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed questionnaire at baseline assessing aspirin use, cardiovascular disease status, and AMD risk factors. Age-related macular degeneration was graded side-by-side from retinal photographs taken at each study visit to assess the incidence of neovascular (wet) AMD and geographic atrophy (dry AMD) according to the international AMD classification. Results: Of 2389 baseline participants with follow-up data available, 257 individuals (10.8%) were regular aspirin users and 63 of the 2389 developed neovascular AMD. Persons who were regular aspirin users were more likely to have incident neovascular AMD: the 15-year cumulative incidence was 9.3% in users and 3.7% in nonusers. After adjustment for age, sex, smoking, history of cardiovascular disease, systolic blood pressure, and body mass index, persons who were regular aspirin users had a higher risk of developing neovascular AMD (odds ratio [OR], 2.46; 95% CI, 1.25-4.83). The association showed a dose-response effect (multivariate-adjusted P=.01 for trend). Aspirin use was not associated with the incidence of geographic atrophy (multivariate-adjusted OR, 0.99; 95% CI, 0.59-1.65). Conclusion: Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking. © 2013 American Medical Association. All rights reserved.
Source Title: JAMA Internal Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/109685
ISSN: 21686106
DOI: 10.1001/jamainternmed.2013.1583
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

40
checked on Apr 10, 2018

WEB OF SCIENCETM
Citations

31
checked on Apr 10, 2018

Page view(s)

17
checked on Mar 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.