Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.amjcard.2008.02.094
Title: Risk Prediction of Coronary Heart Disease Based on Retinal Vascular Caliber (from the Atherosclerosis Risk In Communities [ARIC] Study)
Authors: McGeechan, K.
Liew, G.
Macaskill, P.
Irwig, L.
Klein, R.
Sharrett, A.R.
Klein, B.E.K.
Wang, J.J.
Chambless, L.E.
Wong, T.Y. 
Issue Date: 7-Jul-2008
Citation: McGeechan, K., Liew, G., Macaskill, P., Irwig, L., Klein, R., Sharrett, A.R., Klein, B.E.K., Wang, J.J., Chambless, L.E., Wong, T.Y. (2008-07-07). Risk Prediction of Coronary Heart Disease Based on Retinal Vascular Caliber (from the Atherosclerosis Risk In Communities [ARIC] Study). American Journal of Cardiology 102 (1) : 58-63. ScholarBank@NUS Repository. https://doi.org/10.1016/j.amjcard.2008.02.094
Abstract: Recent studies showed that such retinal vascular signs as quantitative retinal vascular caliber were associated with increased risk of incident coronary heart disease (CHD), but whether these retinal vascular signs add to the prediction of CHD over and above traditional CHD risk factors was not addressed. Whether these signs add to the prediction of CHD over and above the Framingham risk score in people (n = 9,155) without diabetes selected from the ARIC Study was investigated. Incident CHD was ascertained using standardized methods, and retinal vascular caliber and other retinal signs were measured from retinal photographs. After a mean of 8.8 years of follow-up, there were 700 incident CHD events. Women with wider retinal venular caliber (hazard ratio 1.27/1-SD increase, 95% confidence interval 1.08 to 1.50) and narrower retinal arteriolar caliber (hazard ratio 1.31/1-SD decrease, 95% confidence interval 1.10 to 1.56) had a higher risk of incident CHD after adjusting for Framingham risk score variables. Area under the receiver operator characteristic curve increased from 0.695 to 0.706 (1.7% increase) with the addition of retinal vascular caliber to the Framingham risk model. Risk prediction models with and without retinal vascular caliber both fitted the data and were well calibrated for women. In men, retinal vascular caliber was not associated with CHD risk after adjustment. Other retinal vascular signs were not associated with 10-year incident CHD in men or women. In conclusion, although retinal vascular caliber independently predicted CHD risk in women, the incremental predictive ability over that of the Framingham model was modest and unlikely to translate meaningfully into clinical practice. © 2008 Elsevier Inc. All rights reserved.
Source Title: American Journal of Cardiology
URI: http://scholarbank.nus.edu.sg/handle/10635/109631
ISSN: 00029149
DOI: 10.1016/j.amjcard.2008.02.094
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

55
checked on Jun 18, 2018

WEB OF SCIENCETM
Citations

53
checked on Jun 6, 2018

Page view(s)

42
checked on Jun 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.