Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2013.11.025
Title: Preparation and characterization of 4-isopropylcalix[4]arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography
Authors: Chelvi, S.K.T.
Zhao, J.
Chen, L.
Yan, S.
Yin, X.
Sun, J.
Yong, E.L.
Wei, Q.
Gong, Y. 
Keywords: β-Cyclodextrin
4-Isopropylcalix[4]arene, Chiral separation
Chiral stationary phase
High-performance liquid chromatography
Issue Date: 10-Jan-2014
Citation: Chelvi, S.K.T., Zhao, J., Chen, L., Yan, S., Yin, X., Sun, J., Yong, E.L., Wei, Q., Gong, Y. (2014-01-10). Preparation and characterization of 4-isopropylcalix[4]arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)-propylsilyl-appended silica particles as chiral stationary phase for high-performance liquid chromatography. Journal of Chromatography A 1324 : 104-108. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2013.11.025
Abstract: A new type of 4-isopropylcalix[4]arene-capped (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)propylsilyl-appended silica particles (IPC4CD-HPS) has been prepared by treatment of bromoacetate-substituted (3-(2-O-β-cyclodextrin)-2-hydroxypropoxy)propylsilyl-appended silica particles (BACD-HPS) with 4-isopropylcalix[4]arene oxyanions in anhydrous N-methyl-2-pyrrolidone. The bonded silica IPC4CD-HPS has been successfully used as chiral stationary phase (CSP) in high-performance liquid chromatography (HPLC) for the first time. The synthetic stationary phase was characterized by means of elemental analysis and Fourier transform infrared spectroscopy. This new CSP has a chiral selector with two anchored functional moieties: 4-isopropylcalix[4]arene and β-cyclodextrin. The chromatographic performance of IPC4CD-HPS was investigated by separation of positional isomers of several disubstituted benzenes and enantiomers of some chiral drug compounds under reversed-phase conditions. The results showed that IPC4CD-HPS had excellent selectivity for the separation of aromatic positional isomers and enantiomers of chiral compounds due to the cooperative functioning of the anchored 4-isopropylcalix[4]arenes and β-cyclodextrins. © 2013 Elsevier B.V.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/109530
ISSN: 00219673
DOI: 10.1016/j.chroma.2013.11.025
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