Please use this identifier to cite or link to this item:
https://doi.org/10.2174/0929867311320260009
Title: | Fenofibrate: A new treatment for diabetic retinopathy. molecular mechanisms and future perspectives | Authors: | Simó, R. Roy, S. Behar-Cohen, F. Keech, A. Mitchell, P. Wong, T.Y. |
Keywords: | Diabetic retinopathy Fenofibrate Mode of action Pathogenesis Type 2 diabetes |
Issue Date: | Sep-2013 | Citation: | Simó, R., Roy, S., Behar-Cohen, F., Keech, A., Mitchell, P., Wong, T.Y. (2013-09). Fenofibrate: A new treatment for diabetic retinopathy. molecular mechanisms and future perspectives. Current Medicinal Chemistry 20 (26) : 3258-3266. ScholarBank@NUS Repository. https://doi.org/10.2174/0929867311320260009 | Abstract: | Despite improving standards of care, people with diabetes remain at risk of development and progression of diabetic retinopathy (DR) and visual impairment. Identifying novel therapeutic approaches, preferably targeting more than one pathogenic pathway in DR, and at an earlier stage of disease, is attractive. There is now consistent evidence from two major trials, the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study and the Action to Control Cardiovascular Risk in Diabetes Eye (ACCORD-Eye) study, totalling 11,388 people with type 2 diabetes (5,701 treated with fenofibrate) that fenofibrate reduces the risk of development and progression of DR. Therefore, fenofibrate may be considered a preventive strategy for patients without DR or early intervention strategy for those with mild DR. A number of putative therapeutic mechanisms for fenofibrate, both dependent and independent of lipids, have been proposed. A deeper understanding of the mode of action of fenofibrate will further help to define how best to use fenofibrate clinically as an adjunct to current management of DR. © 2013 Bentham Science Publishers. | Source Title: | Current Medicinal Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/109343 | ISSN: | 09298673 | DOI: | 10.2174/0929867311320260009 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.