Please use this identifier to cite or link to this item:
|Title:||Dual-colour HER2/chromosome 17 chromogenic in situ hybridisation enables accurate assessment of HER2 genomic status in ovarian tumours|
|Citation:||Yan, B., Choo, S.N., Mulyadi, P., Srivastava, S., Ong, C.W., Yong, K.J., Putti, T., Salto-Tellez, M., Lim, G.S.D. (2011-12). Dual-colour HER2/chromosome 17 chromogenic in situ hybridisation enables accurate assessment of HER2 genomic status in ovarian tumours. Journal of Clinical Pathology 64 (12) : 1097-1101. ScholarBank@NUS Repository. https://doi.org/10.1136/jclinpath-2011-200082|
|Abstract:||Background: Ovarian cancer is a leading cause of gynaecological cancer-related morbidity and mortality. There has been increasing interest in the potential utility of anti-human epidermal growth factor receptor 2 (anti- HER2) agents in the treatment of this disease, with the attendant need to identify suitable predictive biomarkers of response to treatment. Aims/methods: The authors studied the prevalence of HER2 genomic amplification and overexpression in 85 ovarian tumours in the local patient cohort of this study, as well as the concordance rate between immunohistochemistry, fluorescent in situ hybridisation (FISH) and a dual-colour HER2/chromosome 17 centromere chromogenic in situ hybridisation (CISH) assay. Results: The authors identified HER2 genomic amplification and protein overexpression in 35.3% (6/17) and 29.4% (5/17), respectively, of primary ovarian mucinous carcinomas. No other cancer subtypes displayed HER2 amplification or protein overexpression. The authors also found a perfect concordance between FISH and dual-colour CISH analysis (κ coefficient 1.0, p|
|Source Title:||Journal of Clinical Pathology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 13, 2018
WEB OF SCIENCETM
checked on Jun 12, 2018
checked on Jul 6, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.