Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.11-7510
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dc.titleCandidate gene association study for diabetic retinopathy in persons with type 2 diabetes: The candidate gene association resource (CARe)
dc.contributor.authorSobrin, L.
dc.contributor.authorGreen, T.
dc.contributor.authorSim, X.
dc.contributor.authorJensen, R.A.
dc.contributor.authorShyong Tai, E.
dc.contributor.authorTay, W.T.
dc.contributor.authorWang, J.J.
dc.contributor.authorMitchell, P.
dc.contributor.authorSandholm, N.
dc.contributor.authorLiu, Y.
dc.contributor.authorHietala, K.
dc.contributor.authorIyengar, S.K.
dc.contributor.authorBrooks, M.
dc.contributor.authorBuraczynska, M.
dc.contributor.authorvan Zuydam, N.
dc.contributor.authorSmith, A.V.
dc.contributor.authorGudnason, V.
dc.contributor.authorDoney, A.S.F.
dc.contributor.authorMorris, A.D.
dc.contributor.authorLeese, G.P.
dc.contributor.authorPalmer, C.N.A.
dc.contributor.authorSwaroop, A.
dc.contributor.authorTaylor Jr., H.A.
dc.contributor.authorWilson, J.G.
dc.contributor.authorPenman, A.
dc.contributor.authorChen, C.J.
dc.contributor.authorGroop, P.-H.
dc.contributor.authorSaw, S.-M.
dc.contributor.authorAung, T.
dc.contributor.authorKlein, B.E.
dc.contributor.authorRotter, J.I.
dc.contributor.authorSiscovick, D.S.
dc.contributor.authorCotch, M.F.
dc.contributor.authorKlein, R.
dc.contributor.authorDaly, M.J.
dc.contributor.authorWong, T.Y.
dc.date.accessioned2014-11-26T07:43:18Z
dc.date.available2014-11-26T07:43:18Z
dc.date.issued2011-09
dc.identifier.citationSobrin, L., Green, T., Sim, X., Jensen, R.A., Shyong Tai, E., Tay, W.T., Wang, J.J., Mitchell, P., Sandholm, N., Liu, Y., Hietala, K., Iyengar, S.K., Brooks, M., Buraczynska, M., van Zuydam, N., Smith, A.V., Gudnason, V., Doney, A.S.F., Morris, A.D., Leese, G.P., Palmer, C.N.A., Swaroop, A., Taylor Jr., H.A., Wilson, J.G., Penman, A., Chen, C.J., Groop, P.-H., Saw, S.-M., Aung, T., Klein, B.E., Rotter, J.I., Siscovick, D.S., Cotch, M.F., Klein, R., Daly, M.J., Wong, T.Y. (2011-09). Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: The candidate gene association resource (CARe). Investigative Ophthalmology and Visual Science 52 (10) : 7593-7602. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.11-7510
dc.identifier.issn01460404
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/109224
dc.description.abstractPurpose. To investigate whether variants in cardiovascular candidate genes, some of which have been previously associated with type 2 diabetes (T2D), diabetic retinopathy (DR), and diabetic nephropathy (DN), are associated with DR in the Candidate gene Association Resource (CARe). Methods. Persons with T2D who were enrolled in the study (n = 2691) had fundus photography and genotyping of single nucleotide polymorphisms (SNPs) in 2000 candidate genes. Two case definitions were investigated: Early Treatment Diabetic Retinopathy Study (ETDRS) grades ≥14 and ≥30. The χ 2 analyses for each CARe cohort were combined by Cochran-Mantel-Haenszel (CMH) pooling of odds ratios (ORs) and corrected for multiple hypothesis testing. Logistic regression was performed with adjustment for other DR risk factors. Results from replication in independent cohorts were analyzed with CMH meta-analysis methods. Results. Among 39 genes previously associated with DR, DN, or T2D, three SNPs in P-selectin (SELP) were associated with DR. The strongest association was to rs6128 (OR = 0.43, P = 0.0001, after Bonferroni correction). These associations remained significant after adjustment for DR risk factors. Among other genes examined, several variants were associated with DR with significant P values, including rs6856425 tagging α-L-iduronidase (IDUA) (P = 2.1 × 10 -5, after Bonferroni correction). However, replication in independent cohorts did not reveal study-wide significant effects. The P values after replication were 0.55 and 0.10 for rs6128 and rs6856425, respectively. Conclusions. Genes associated with DN, T2D, and vascular diseases do not appear to be consistently associated with DR. A few genetic variants associated with DR, particularly those in SELP and near IDUA, should be investigated in additional DR cohorts. © 2011 The Association for Research in Vision and Ophthalmology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1167/iovs.11-7510
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1167/iovs.11-7510
dc.description.sourcetitleInvestigative Ophthalmology and Visual Science
dc.description.volume52
dc.description.issue10
dc.description.page7593-7602
dc.description.codenIOVSD
dc.identifier.isiut000295467200072
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