Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bone.2012.03.006
Title: Serum free estradiol and estrogen receptor-α mediated activity are related to decreased incident hip fractures in older women
Authors: Lim, V.W.
Li, J.
Gong, Y. 
Yuan, J.-M.
Wu, T.S.
Hammond, G.L.
Jin, A.
Koh, W.-P. 
Yong, E.L.
Keywords: Asian women
ERα-mediated estrogenic activity
Estrogens
Hip fracture
Population-based
Issue Date: Jun-2012
Source: Lim, V.W., Li, J., Gong, Y., Yuan, J.-M., Wu, T.S., Hammond, G.L., Jin, A., Koh, W.-P., Yong, E.L. (2012-06). Serum free estradiol and estrogen receptor-α mediated activity are related to decreased incident hip fractures in older women. Bone 50 (6) : 1311-1316. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bone.2012.03.006
Abstract: There is paucity of data from Asian women on the association between serum estrogens and osteoporotic hip fracture risk. We conducted a case-control study nested within a population-based prospective cohort, The Singapore Chinese Health Study, to evaluate serum estrogens levels, ERα-mediated estrogenic activity and hip fracture risk in postmenopausal Asian women. Among 35,298 women who were recruited between 1993 and 1998, 15,410 women donated blood for research between 1999 and 2004. From this subcohort, we identified 140 cases who subsequently suffered hip fracture after blood donation, and 278 age-matched controls. Serum levels of total estrone, estradiol and sex hormone binding globulin levels were measured in a blinded fashion among cases and controls. ERα-mediated estrogenic activity of serum samples was quantified using a sensitive ERα-driven cell bioassay. Women with hip fracture had lower serum estrogens than control women. Compared to the lowest quintile, women in the highest quintile of free estradiol exhibited a statistically significant 57% reduction in risk of hip fracture (95% confidence interval (CI), 6-80%), with a dose-dependent relationship (p for trend = 0.021). High levels of ERα-mediated estrogenic activity were also associated with decreased risk of hip fracture (p for trend = 0.048). Overall, women with relatively high levels of both free estradiol and ERα-mediated estrogenic activity had a 55% reduction in hip fracture risk (95% CI, 17-76%) compared to women with low levels of both. High levels of free estradiol and ERα-mediated estrogen activity in sera were associated with reduced hip fracture risk in Chinese postmenopausal women. © 2012 Elsevier Inc.
Source Title: Bone
URI: http://scholarbank.nus.edu.sg/handle/10635/109046
ISSN: 87563282
DOI: 10.1016/j.bone.2012.03.006
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

8
checked on Feb 14, 2018

WEB OF SCIENCETM
Citations

6
checked on Jan 23, 2018

Page view(s)

38
checked on Feb 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.