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|Title:||Serum estrogen receptor bioactivity and breast cancer risk among postmenopausal women|
Estrogen receptor bioassay
|Citation:||Lim, V.W., Li, J., Gong, Y., Jin, A., Yuan, J.-M., Yong, E.L., Koh, W.-P. (2014). Serum estrogen receptor bioactivity and breast cancer risk among postmenopausal women. Endocrine-Related Cancer 21 (2) : 263-273. ScholarBank@NUS Repository. https://doi.org/10.1530/ERC-13-0233|
|Abstract:||The estrogen levels of Asian women are different from those of Western women, and this could affect estrogen receptor (ER) bioactivity and breast cancer risk. We conducted a case'control study in 169 postmenopausal breast cancer cases and 426 matched controls nested within a population-based prospective cohort study, the Singapore Chinese Health Study, to evaluate the serum levels of estrogens and their receptor (ERa and ERb)-mediated estrogenic activities in relation to breast cancer risk. Breast cancer cases had higher levels of estrogens and ER-mediated bioactivities in baseline serum than the controls. Compared with those in the lowest quartile, women in the highest quartile for estrone (E1) or ERa-mediated bioactivity had increased breast cancer risk. After additional adjustment for ERb bioactivity, free estradiol, and E1 levels, serum ERa-mediated bioactivity remained associated with increased breast cancer risk. Compared with those in the lowest quartile, women in the highest quartile for ERa-mediated bioactivity had an odds ratio of 2.39 (95% CIZ1.17'4.88; P for trendZ0.016). Conversely, the positive association between E1 and cancer risk became null after adjustment for ERa-mediated bioactivity, suggesting that the effect of E1 could be mediated through ERa. Factor(s) contributing to increased ERa-mediated estrogenic bioactivity in serum and its role as a predictor for breast cancer risk need to be validated in future studies. © 2014 Society for Endocrinology.|
|Source Title:||Endocrine-Related Cancer|
|Appears in Collections:||Staff Publications|
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