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Title: Prevalence of and risk factors for MRSA colonization in HIV-positive outpatients in Singapore
Authors: Kyaw, W.M.
Lee, L.K.
Siong, W.C. 
Ping, A.C.L.
Ang, B.
Leo, Y.S.
Keywords: Colonization
Methicillin-resistant Staphylococcus auerus
Risk factors
Issue Date: 6-Nov-2012
Citation: Kyaw, W.M., Lee, L.K., Siong, W.C., Ping, A.C.L., Ang, B., Leo, Y.S. (2012-11-06). Prevalence of and risk factors for MRSA colonization in HIV-positive outpatients in Singapore. AIDS Research and Therapy 9 : -. ScholarBank@NUS Repository.
Abstract: Background: Whilst there have been studies on the risks and outcomes of MRSA colonization and infections in HIV-positive patients, local data is limited on the risk factors for MRSA colonization among these patients. We undertook this study in a tertiary HIV care centre to document the risk factors for colonization and to determine the prevalence of MRSA colonization among HIV-positive outpatients in Singapore.Methods: This was a cross-sectional study in which factors associated with MRSA positivity among patients with HIV infection were evaluated. A set of standardized questionnaire and data collection forms were available to interview all recruited patients. Following the interview, trained nurses collected swabs from the anterior nares/axilla/groin (NAG), throat and peri-anal regions. Information on demographics, clinical history, laboratory results and hospitalization history were retrieved from medical records.Results: MRSA was detected in swab cultures from at least 1 site in 15 patients (5.1%). Inclusion of throat and/or peri-anal swabs increased the sensitivity of NAG screening by 20%. Predictors for MRSA colonization among HIV-positive patients were age, history of pneumonia, lymphoma, presence of a percutaneous device within the past 12 months, history of household members hospitalized more than two times within the past 12 months, and a most recent CD4 count less than 200.Conclusions: This study highlights that a proportion of MRSA carriers would have been undetected without multiple-site screening cultures. This study could shed insight into identifying patients at risk of MRSA colonization upon hospital visit and this may suggest that a risk factor-based approach for MRSA surveillance focusing on high risk populations could be considered. © 2012 Kyaw et al.; licensee BioMed Central Ltd.
Source Title: AIDS Research and Therapy
ISSN: 17426405
DOI: 10.1186/1742-6405-9-33
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