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https://doi.org/10.1038/ng.2561
| Title: | Genome-wide association studies identify four ER negative-specific breast cancer risk loci | Authors: | Garcia-Closas, M. Couch, F.J. Lindstrom, S. Michailidou, K. Schmidt, M.K. Brook, M.N. Orr, N. Rhie, S.K. Riboli, E. Feigelson, H.S. Le Marchand, L. Buring, J.E. Eccles, D. Miron, P. Fasching, P.A. Brauch, H. Chang-Claude, J. Carpenter, J. Godwin, A.K. Nevanlinna, H. Giles, G.G. Cox, A. Hopper, J.L. Bolla, M.K. Wang, Q. Dennis, J. Dicks, E. Howat, W.J. Schoof, N. Bojesen, S.E. Lambrechts, D. Broeks, A. Andrulis, I.L. Guénel, P. Burwinkel, B. Sawyer, E.J. Hollestelle, A. Fletcher, O. Winqvist, R. Brenner, H. Mannermaa, A. Hamann, U. Meindl, A. Lindblom, A. Zheng, W. Devillee, P. Goldberg, M.S. Lubinski, J. Kristensen, V. Swerdlow, A. Anton-Culver, H. Dörk, T. Muir, K. Matsuo, K. Wu, A.H. Radice, P. Teo, S.H. Shu, X.-O. Blot, W. Kang, D. Hartman, M. Sangrajrang, S. Shen, C.-Y. Southey, M.C. Park, D.J. Hammet, F. Stone, J. Veer, L.J.V. Rutgers, E.J. Lophatananon, A. Stewart-Brown, S. Siriwanarangsan, P. Peto, J. Schrauder, M.G. Ekici, A.B. Beckmann, M.W. Dos Santos Silva, I. Johnson, N. Warren, H. Tomlinson, I. Kerin, M.J. Miller, N. Marme, F. Schneeweiss, A. Sohn, C. Truong, T. Laurent-Puig, P. Kerbrat, P. Nordestgaard, Bø.G. Nielsen, S.F. Flyger, H. Milne, R.L. Perez, J.I.A. Menéndez, P. Müller, H. Arndt, V. Stegmaier, C. Lichtner, P. Lochmann, M. Justenhoven, C. Ko, Y.-D. Muranen, T.A. Aittomäki, K. Blomqvist, C. Greco, D. Heikkinen, T. Ito, H. Iwata, H. Yatabe, Y. Antonenkova, N.N. Margolin, S. Kataja, V. Kosma, V.-M. Hartikainen, J.M. Balleine, R. Tseng, C.-C. Berg, D.V.D. Stram, D.O. Neven, P. Dieudonné, A.-S. Leunen, K. Rudolph, A. Nickels, S. Flesch-Janys, D. Peterlongo, P. Peissel, B. Bernard, L. Olson, J.E. Wang, X. Stevens, K. Severi, G. Baglietto, L. McLean, C. Coetzee, G.A. Feng, Y. Henderson, B.E. Schumacher, F. Bogdanova, N.V. Labrèche, F. Dumont, M. Yip, C.H. Taib, N.A.M. Cheng, C.-Y. Shrubsole, M. Long, J. Pylkäs, K. Jukkola-Vuorinen, A. Kauppila, S. Knight, J.A. Glendon, G. Mulligan, A.M. Tollenaar, R.A.E.M. Seynaeve, C.M. Kriege, M. Hooning, M.J. Van Den Ouweland, A.M.W. Van Deurzen, C.H.M. Lu, W. Gao, Y.-T. Cai, H. Balasubramanian, S.P. Cross, S.S. Reed, M.W.R. Signorello, L. Cai, Q. Shah, M. Miao, H. Chan, C.W. Chia, K.S. Jakubowska, A. Jaworska, K. Durda, K. Hsiung, C.-N. Wu, P.-E. Yu, J.-C. Ashworth, A. Jones, M. Tessier, D.C. González-Neira, A. Pita, G. Alonso, M.R. Vincent, D. Bacot, F. Ambrosone, C.B. Bandera, E.V. John, E.M. Chen, G.K. Hu, J.J. Rodriguez-Gil, J.L. Bernstein, L. Press, M.F. Ziegler, R.G. Millikan, R.M. Deming-Halverson, S.L. Nyante, S. Ingles, S.A. Waisfisz, Q. Tsimiklis, H. Makalic, E. Schmidt, D. Bui, M. Gibson, L. Müller-Myhsok, B. Schmutzler, R.K. Hein, R. Dahmen, N. Beckmann, L. Aaltonen, K. Czene, K. Irwanto, A. Liu, J. Turnbull, C. Rahman, N. Meijers-Heijboer, H. Uitterlinden, A.G. Rivadeneira, F. Olswold, C. Slager, S. Pilarski, R. Ademuyiwa, F. Konstantopoulou, I. Martin, N.G. Montgomery, G.W. Slamon, D.J. Rauh, C. Lux, M.P. Jud, S.M. Bruning, T. Weaver, J. Sharma, P. Pathak, H. Tapper, W. Gerty, S. Durcan, L. Trichopoulos, D. Tumino, R. Peeters, P.H. Kaaks, R. Campa, D. Canzian, F. Weiderpass, E. Johansson, M. Khaw, K.-T. Travis, R. Clavel-Chapelon, F. Kolonel, L.N. Chen, C. Beck, A. Hankinson, S.E. Berg, C.D. Hoover, R.N. Lissowska, J. Figueroa, J.D. Chasman, D.I. Gaudet, M.M. Diver, W.R. Willett, W.C. Hunter, D.J. Simard, J. Benitez, J. Dunning, A.M. Sherman, M.E. Chenevix-Trench, G. Chanock, S.J. Hall, P. Pharoah, P.D.P. Vachon, C. Easton, D.F. Haiman, C.A. Kraft, P. |
Issue Date: | Apr-2013 | Citation: | Garcia-Closas, M., Couch, F.J., Lindstrom, S., Michailidou, K., Schmidt, M.K., Brook, M.N., Orr, N., Rhie, S.K., Riboli, E., Feigelson, H.S., Le Marchand, L., Buring, J.E., Eccles, D., Miron, P., Fasching, P.A., Brauch, H., Chang-Claude, J., Carpenter, J., Godwin, A.K., Nevanlinna, H., Giles, G.G., Cox, A., Hopper, J.L., Bolla, M.K., Wang, Q., Dennis, J., Dicks, E., Howat, W.J., Schoof, N., Bojesen, S.E., Lambrechts, D., Broeks, A., Andrulis, I.L., Guénel, P., Burwinkel, B., Sawyer, E.J., Hollestelle, A., Fletcher, O., Winqvist, R., Brenner, H., Mannermaa, A., Hamann, U., Meindl, A., Lindblom, A., Zheng, W., Devillee, P., Goldberg, M.S., Lubinski, J., Kristensen, V., Swerdlow, A., Anton-Culver, H., Dörk, T., Muir, K., Matsuo, K., Wu, A.H., Radice, P., Teo, S.H., Shu, X.-O., Blot, W., Kang, D., Hartman, M., Sangrajrang, S., Shen, C.-Y., Southey, M.C., Park, D.J., Hammet, F., Stone, J., Veer, L.J.V., Rutgers, E.J., Lophatananon, A., Stewart-Brown, S., Siriwanarangsan, P., Peto, J., Schrauder, M.G., Ekici, A.B., Beckmann, M.W., Dos Santos Silva, I., Johnson, N., Warren, H., Tomlinson, I., Kerin, M.J., Miller, N., Marme, F., Schneeweiss, A., Sohn, C., Truong, T., Laurent-Puig, P., Kerbrat, P., Nordestgaard, Bø.G., Nielsen, S.F., Flyger, H., Milne, R.L., Perez, J.I.A., Menéndez, P., Müller, H., Arndt, V., Stegmaier, C., Lichtner, P., Lochmann, M., Justenhoven, C., Ko, Y.-D., Muranen, T.A., Aittomäki, K., Blomqvist, C., Greco, D., Heikkinen, T., Ito, H., Iwata, H., Yatabe, Y., Antonenkova, N.N., Margolin, S., Kataja, V., Kosma, V.-M., Hartikainen, J.M., Balleine, R., Tseng, C.-C., Berg, D.V.D., Stram, D.O., Neven, P., Dieudonné, A.-S., Leunen, K., Rudolph, A., Nickels, S., Flesch-Janys, D., Peterlongo, P., Peissel, B., Bernard, L., Olson, J.E., Wang, X., Stevens, K., Severi, G., Baglietto, L., McLean, C., Coetzee, G.A., Feng, Y., Henderson, B.E., Schumacher, F., Bogdanova, N.V., Labrèche, F., Dumont, M., Yip, C.H., Taib, N.A.M., Cheng, C.-Y., Shrubsole, M., Long, J., Pylkäs, K., Jukkola-Vuorinen, A., Kauppila, S., Knight, J.A., Glendon, G., Mulligan, A.M., Tollenaar, R.A.E.M., Seynaeve, C.M., Kriege, M., Hooning, M.J., Van Den Ouweland, A.M.W., Van Deurzen, C.H.M., Lu, W., Gao, Y.-T., Cai, H., Balasubramanian, S.P., Cross, S.S., Reed, M.W.R., Signorello, L., Cai, Q., Shah, M., Miao, H., Chan, C.W., Chia, K.S., Jakubowska, A., Jaworska, K., Durda, K., Hsiung, C.-N., Wu, P.-E., Yu, J.-C., Ashworth, A., Jones, M., Tessier, D.C., González-Neira, A., Pita, G., Alonso, M.R., Vincent, D., Bacot, F., Ambrosone, C.B., Bandera, E.V., John, E.M., Chen, G.K., Hu, J.J., Rodriguez-Gil, J.L., Bernstein, L., Press, M.F., Ziegler, R.G., Millikan, R.M., Deming-Halverson, S.L., Nyante, S., Ingles, S.A., Waisfisz, Q., Tsimiklis, H., Makalic, E., Schmidt, D., Bui, M., Gibson, L., Müller-Myhsok, B., Schmutzler, R.K., Hein, R., Dahmen, N., Beckmann, L., Aaltonen, K., Czene, K., Irwanto, A., Liu, J., Turnbull, C., Rahman, N., Meijers-Heijboer, H., Uitterlinden, A.G., Rivadeneira, F., Olswold, C., Slager, S., Pilarski, R., Ademuyiwa, F., Konstantopoulou, I., Martin, N.G., Montgomery, G.W., Slamon, D.J., Rauh, C., Lux, M.P., Jud, S.M., Bruning, T., Weaver, J., Sharma, P., Pathak, H., Tapper, W., Gerty, S., Durcan, L., Trichopoulos, D., Tumino, R., Peeters, P.H., Kaaks, R., Campa, D., Canzian, F., Weiderpass, E., Johansson, M., Khaw, K.-T., Travis, R., Clavel-Chapelon, F., Kolonel, L.N., Chen, C., Beck, A., Hankinson, S.E., Berg, C.D., Hoover, R.N., Lissowska, J., Figueroa, J.D., Chasman, D.I., Gaudet, M.M., Diver, W.R., Willett, W.C., Hunter, D.J., Simard, J., Benitez, J., Dunning, A.M., Sherman, M.E., Chenevix-Trench, G., Chanock, S.J., Hall, P., Pharoah, P.D.P., Vachon, C., Easton, D.F., Haiman, C.A., Kraft, P. (2013-04). Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nature Genetics 45 (4) : 392-398. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2561 | Abstract: | Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10-12 and LGR6, P = 1.4 × 10-8), 2p24.1 (P = 4.6 × 10-8) and 16q12.2 (FTO, P = 4.0 × 10-8), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers. | Source Title: | Nature Genetics | URI: | http://scholarbank.nus.edu.sg/handle/10635/108942 | ISSN: | 10614036 | DOI: | 10.1038/ng.2561 |
| Appears in Collections: | Staff Publications |
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