Please use this identifier to cite or link to this item: https://doi.org/10.1111/irv.12129
Title: Factors influencing infection by pandemic influenza A(H1N1)pdm09 over three epidemic waves in Singapore
Authors: Chen, M.I.C. 
Cook, A.R. 
Lim, W.Y. 
Lin, R.
Cui, L.
Barr, I.G.
Kelso, A.
Chow, V.T.
Leo, Y.S.
Hsu, J.P.
Shaw, R.
Chew, S.
Yap, J.K.
Phoon, M.C.
Koh, H.W.L.
Zheng, H.
Tan, L.
Lee, V.J. 
Keywords: Epidemic waves
H1N1pdm09
Haemagglutination inhibition
Risk factors
Seroconversion
Seroepidemiology
Issue Date: Nov-2013
Citation: Chen, M.I.C., Cook, A.R., Lim, W.Y., Lin, R., Cui, L., Barr, I.G., Kelso, A., Chow, V.T., Leo, Y.S., Hsu, J.P., Shaw, R., Chew, S., Yap, J.K., Phoon, M.C., Koh, H.W.L., Zheng, H., Tan, L., Lee, V.J. (2013-11). Factors influencing infection by pandemic influenza A(H1N1)pdm09 over three epidemic waves in Singapore. Influenza and other Respiratory Viruses 7 (6) : 1380-1389. ScholarBank@NUS Repository. https://doi.org/10.1111/irv.12129
Abstract: Introduction: Previous influenza pandemics had second and on occasion third waves in many countries that were at times more severe than the initial pandemic waves. Objective: This study aims to determine the seroepidemiology of successive waves of H1N1pdm09 infections in Singapore and the overall risks of infection. Methods: We performed a cohort study amongst 838 adults, with blood samples provided upon recruitment and at 5 points from 2009 to 2011 and tested by haemagglutination inhibition (HI) with A/California/7/2009 (H1N1pdm09). Surveys on key demographic and clinical information were conducted at regular intervals, and associations between seroconversion and these variables were investigated. Results: After the initial wave from June to September 2009, second and third waves occurred from November 2009 to February 2010 and April to June 2010, respectively. Seroconversion was 13·5% during the first wave and decreased to 6·2% and 6·8% in subsequent waves. Across the three waves, the elderly and those with higher starting HI titres were at lower risk of seroconversion, while those with larger households were at greater risk. Those with higher starting HI titres were also less likely to have an acute respiratory infection. Conclusions: The second and third waves in Singapore had lower serological attack rates than the first wave. The elderly and those with higher HI titres had lower risk, while those in larger households had higher risk of seroconversion. © 2013 John Wiley & Sons Ltd.
Source Title: Influenza and other Respiratory Viruses
URI: http://scholarbank.nus.edu.sg/handle/10635/108925
ISSN: 17502640
DOI: 10.1111/irv.12129
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Jun 21, 2018

WEB OF SCIENCETM
Citations

11
checked on May 9, 2018

Page view(s)

50
checked on Jun 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.