Please use this identifier to cite or link to this item:
|Title:||Change of mammographic density predicts the risk of contralateral breast cancer - a case-control study|
Contralateral breast cancer
|Source:||Sandberg, M.E.C., Li, J., Hall, P., Hartman, M., dos-Santos-Silva, I., Humphreys, K., Czene, K. (2013-07-22). Change of mammographic density predicts the risk of contralateral breast cancer - a case-control study. Breast Cancer Research 15 (4) : -. ScholarBank@NUS Repository. https://doi.org/10.1186/bcr3451|
|Abstract:||Introduction: Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).Methods: We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.Results: Patients who experienced ≥10% absolute decrease in percent density had a 55% decreased odds of CBC (OR = 0.45 95% CI: 0.24 to 0.84) relative to patients who had little or no change in density from baseline to first follow-up mammogram (mean = 1.6 (SD = 0.6) years after diagnosis), whereas among those who experienced an absolute increase in percent density we could not detect any effect on the odds of CBC (OR = 0.83 95% CI: 0.24 to 2.87). Conclusion: Decrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment. © 2013 Sandberg et al.; licensee BioMed Central Ltd.|
|Source Title:||Breast Cancer Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 14, 2018
WEB OF SCIENCETM
checked on Feb 14, 2018
checked on Feb 11, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.