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Title: Familial effects on ischemic stroke the role of sibling kinship, sex, and age of onset
Authors: Kasiman, K. 
Lundholm, C.
Sandin, S.
Malki, N.
Sparén, P.
Ingelsson, E.
Keywords: Epidemiology
Family history
Ischemic stroke
Issue Date: Apr-2012
Citation: Kasiman, K., Lundholm, C., Sandin, S., Malki, N., Sparén, P., Ingelsson, E. (2012-04). Familial effects on ischemic stroke the role of sibling kinship, sex, and age of onset. Circulation: Cardiovascular Genetics 5 (2) : 226-233. ScholarBank@NUS Repository.
Abstract: Background-Previous studies on familial risk of ischemic stroke have supported genetic influence on the disease incidence. This study aimed to characterize these familial effects in a nationwide population-based study by taking into account sibling relations, sex of siblings, and age of onset, with respect to ischemic stroke incidence. Methods and Results-Incident ischemic stroke cases identified from the Swedish Hospital Discharge and Cause of Death Registers between 1987 and 2007 were linked to their stroke-free siblings (study participants), forming an exposed sib-pair. Each exposed sib-pair was matched up to 5 unexposed sib-pairs from the Multi-Generation Registry by birth and calendar years. Incident ischemic stroke risk was assessed using hazard estimates obtained from stratified Cox regression analyses. A total of 30 735 exposed and 152 391 unexposed study participants were included in the analyses. The overall risk of incident ischemic stroke when exposed was significantly increased (relative risk, 1.61; 95% confidence interval, 1.48 -1.75; P
Source Title: Circulation: Cardiovascular Genetics
ISSN: 1942325X
DOI: 10.1161/CIRCGENETICS.111.962241
Appears in Collections:Staff Publications

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