Please use this identifier to cite or link to this item: https://doi.org/10.5664/jcsm.3266
Title: Excessive daytime sleepiness is associated with longer culprit lesion and adverse outcomes in patients with coronary artery disease
Authors: Lee, C.-H.
Ng, W.-Y. 
Hau, W.
Ho, H.-H.
Tai, B.-C. 
Chan, M.Y.
Richards, A.M.
Tan, H.-C.
Keywords: Coronary artery disease
Intravascular ultrasound
Outcomes
Sleepiness
Issue Date: 2013
Citation: Lee, C.-H., Ng, W.-Y., Hau, W., Ho, H.-H., Tai, B.-C., Chan, M.Y., Richards, A.M., Tan, H.-C. (2013). Excessive daytime sleepiness is associated with longer culprit lesion and adverse outcomes in patients with coronary artery disease. Journal of Clinical Sleep Medicine 9 (12) : 1267-1272. ScholarBank@NUS Repository. https://doi.org/10.5664/jcsm.3266
Abstract: Study Objectives: We assessed whether excessive daytime sleepiness was associated with coronary plaque phenotype and subsequent adverse cardiovascular events. Methods: Prospective cohort study. Intravascular ultrasound (IVUS) examination of the culprit coronary stenosis was performed. The Epworth Sleepiness Scale (ESS) questionnaire was administered, and the patients were divided into 2 groups - (1) sleepier and (2) less sleepy - based on the ESS score. Adverse cardiovascular outcomes were defined as cardiac death, myocardial infarction, stroke, unplanned revascularization, or heart failure admission. Results: One hundred seventeen patients undergoing urgent or non-urgent coronary angiography were recruited. Compared with the less sleepy group (ESS ≤ 10, n = 87), the sleepier group (ESS > 10, n = 30) had higher serum levels of total cholesterol and of low-density-lipoprotein cholesterols (p < 0.05 for both). The IVUS examinations indicated coronary stenoses were longer in the sleepier group than in the less sleepy group (p = 0.011). The cumulative incidence of adverse cardiovascular events at 16-month follow-up was higher in the sleepier than the less sleepy group (12.5% versus 6.9%, p = 0.03). Cox regression analysis adjusting for age and smoking showed increased hazard of adverse cardiovascular events in sleepier group as compared to less sleepy group (HR = 3.44, 95% CI 1.01-11.72). Conclusion: In patients presenting with coronary artery disease, excessive daytime sleepiness based on ESS > 10 was associated with longer culprit lesions and future adverse cardiovascular events.
Source Title: Journal of Clinical Sleep Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/108751
ISSN: 15509389
DOI: 10.5664/jcsm.3266
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Dec 12, 2018

WEB OF SCIENCETM
Citations

10
checked on Dec 4, 2018

Page view(s)

46
checked on Dec 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.