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https://scholarbank.nus.edu.sg/handle/10635/108471
Title: | Multivoxel MR spectroscopic imaging - Distinguishing intracranial tumours from non-neoplastic disease | Authors: | Nagar, V.A. Ye, J. Xu, M. Ng, W.-H. Yeo, T.-T. Ong, P.-L. Lim, C.C.T. |
Keywords: | Brain neoplasm Magnetic resonance imaging Nuclear magnetic resonance Spectroscopy |
Issue Date: | May-2007 | Citation: | Nagar, V.A.,Ye, J.,Xu, M.,Ng, W.-H.,Yeo, T.-T.,Ong, P.-L.,Lim, C.C.T. (2007-05). Multivoxel MR spectroscopic imaging - Distinguishing intracranial tumours from non-neoplastic disease. Annals of the Academy of Medicine Singapore 36 (5) : 309-313. ScholarBank@NUS Repository. | Abstract: | Introduction: Multi-voxel MR spectroscopic imaging (MRSI) provides chemical metabolite information that can supplement conventional MR imaging in the study of intracranial neoplasia. Our purpose was to use a robust semi-automated spectroscopic analysis to distinguish intracranial tumours from non-neoplastic disease. Materials and Methods: Twenty intracranial tumours and 15 patients with non-neoplastic disease confirmed on histological examination or serial neuroimaging were studied with 2-dimensional MRSI using point-resolved spectroscopic (PRESS) imaging localisation. Using semi-automated post-processing software, spectra were analysed for peak heights of choline (Cho), creatine (Cr), N-acetyl aspartate (NAA), lactate (Lac) and lipid (Lip). Normalised Cho (nCho) ratios, computed by dividing maximum Cho in the lesion by the normal-appearing brain, were compared between intracranial tumours and non-neoplastic disease. Results: Meningiomas displayed homogenously elevated Cho. Malignant tumours, especially large glioblastoma multiforme, displayed inhomogeneity of metabolites within the tumour. All tumours had elevation of nCho >1 (mean 1.91 ± 0.65), and non-neoplastic diseases had tumour nCho | Source Title: | Annals of the Academy of Medicine Singapore | URI: | http://scholarbank.nus.edu.sg/handle/10635/108471 | ISSN: | 03044602 |
Appears in Collections: | Staff Publications |
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