Please use this identifier to cite or link to this item:
Title: Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals
Authors: Lim, S.C.
Liu, J.J.
Low, H.Q.
Morgenthaler, N.G.
Li, Y.
Yeoh, L.Y.
Wu, Y.S.
Goh, S.K.
Chionh, C.Y.
Tan, S.H.
Kon, Y.C.
Soon, P.C.
Bee, Y.M.
Subramaniam, T.
Sum, C.F.
Chia, K.S. 
Keywords: Candidate genes
Diabetic nephropathy
Issue Date: Jul-2009
Source: Lim, S.C., Liu, J.J., Low, H.Q., Morgenthaler, N.G., Li, Y., Yeoh, L.Y., Wu, Y.S., Goh, S.K., Chionh, C.Y., Tan, S.H., Kon, Y.C., Soon, P.C., Bee, Y.M., Subramaniam, T., Sum, C.F., Chia, K.S. (2009-07). Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals. Diabetologia 52 (7) : 1343-1351. ScholarBank@NUS Repository.
Abstract: Aims/hypothesis: Evolving research suggests that common and rare alleles jointly constitute the genetic landscape of complex disease. We studied the association between 43 pathway-related candidate genes with 'intermediate phenotype' (i.e. corresponding plasma protein) and diabetic nephropathy in a customised microarray of 1,536 SNPs. Methods: In this case-control study of type 2 diabetic Chinese individuals with and without diabetic nephropathy, cases (n∈=∈545) were defined on the basis of a spot urinary albumin/creatinine ratio (ACR)∈>∈113 mg/mmol; the value for controls (n∈=∈503) was ACR∈A, frequency∈=∈0. 252) was correlated with plasma C-terminal pro-endothelin-1 concentrations with an estimated OR for diabetic nephropathy of (heterozygous) 1.26 (0.96-1.66) and (homozygous) 1.87 (1.13-3.12) (p∈=∈0.0072). Nitric oxide synthase 1 (NOS1) 5′ haplotype (TGTC frequency∈=∈0.38) also revealed a suggestive association with diabetic nephropathy: heterozygous 1.26 (0.95-1.67), homozygous 1.57 (1.04-2.35) (p∈=∈0.0073). A rare NADPH oxidase homologue 1 (NOX1)-coding non-synonymous SNP (Arg315His, frequency∈= ∈0.006) was found exclusively among cases. Conclusions/interpretation: Our preliminary observations suggest that common haplotypes from NOX4 and endothelin-1 SNP correlated with plasma Cu/Zn SOD and C-terminal pro-endothelin-1 concentrations, respectively, and might have conferred diabetic nephropathy susceptibility. Common NOS1 and rare NOX1 variants also revealed a suggestive association with diabetic nephropathy. Future studies to validate our observation are needed. © 2009 Springer-Verlag.
Source Title: Diabetologia
ISSN: 0012186X
DOI: 10.1007/s00125-009-1368-x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Mar 8, 2018


checked on Feb 7, 2018

Page view(s)

checked on Mar 12, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.