Please use this identifier to cite or link to this item: https://doi.org/10.1038/nature10405
Title: Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Authors: Ehret, G.B.
Munroe, P.B.
Rice, K.M.
Bochud, M.
Johnson, A.D.
Chasman, D.I.
Smith, A.V.
Tobin, M.D.
Verwoert, G.C.
Hwang, S.-J.
Pihur, V.
Vollenweider, P.
O'Reilly, P.F.
Amin, N.
Bragg-Gresham, J.L.
Teumer, A.
Glazer, N.L.
Launer, L.
Zhao, J.H.
Aulchenko, Y.
Heath, S.
Sober, S.
Parsa, A.
Luan, J.
Arora, P.
Dehghan, A.
Zhang, F.
Lucas, G.
Hicks, A.A.
Jackson, A.U.
Peden, J.F.
Tanaka, T.
Wild, S.H.
Rudan, I.
Igl, W.
Milaneschi, Y.
Parker, A.N.
Fava, C.
Chambers, J.C.
Fox, E.R.
Kumari, M.
Go, M.J.
van der Harst, P.
Kao, W.H.L.
Sjögren, M.
Vinay, D.G.
Alexander, M.
Tabara, Y.
Shaw-Hawkins, S.
Whincup, P.H.
Liu, Y.
Shi, G.
Kuusisto, J.
Tayo, B.
Seielstad, M.
Sim, X. 
Hoang Nguyen, K.-D.
Lehtimäki, T.
Matullo, G.
Wu, Y.
Gaunt, T.R.
Charlotte Onland-Moret, N.
Cooper, M.N.
Platou, C.G.P.
Org, E.
Hardy, R.
Dahgam, S.
Palmen, J.
Vitart, V.
Braund, P.S.
Kuznetsova, T.
Uiterwaal, C.S.P.M.
Adeyemo, A.
Palmas, W.
Campbell, H.
Ludwig, B.
Tomaszewski, M.
Tzoulaki, I.
Palmer, N.D.
Aspelund, T.
Garcia, M.
Chang, Y.-P.C.
O'Connell, J.R.
Steinle, N.I.
Grobbee, D.E.
Arking, D.E.
Kardia, S.L.
Morrison, A.C.
Hernandez, D.
Najjar, S.
McArdle, W.L.
Hadley, D.
Brown, M.J.
Connell, J.M.
Hingorani, A.D.
Day, I.N.M.
Lawlor, D.A.
Beilby, J.P.
Lawrence, R.W.
Clarke, R.
Hopewell, J.C.
Ongen, H.
Dreisbach, A.W.
Li, Y.
Hunter Young, J.
Bis, J.C.
Kähönen, M.
Viikari, J.
Adair, L.S.
Lee, N.R.
Chen, M.-H.
Olden, M.
Pattaro, C.
Bolton, J.A.H.
Köttgen, A.
Bergmann, S.
Mooser, V.
Chaturvedi, N.
Frayling, T.M.
Islam, M.
Jafar, T.H.
Erdmann, J.
Kulkarni, S.R.
Bornstein, S.R.
Grässler, J.
Groop, L.
Voight, B.F.
Kettunen, J.
Howard, P.
Taylor, A.
Guarrera, S.
Ricceri, F.
Emilsson, V.
Plump, A.
Barroso, I.
Khaw, K.-T.
Weder, A.B.
Hunt, S.C.
Sun, Y.V.
Bergman, R.N.
Collins, F.S.
Bonnycastle, L.L.
Scott, L.J.
Stringham, H.M.
Peltonen, L.
Perola, M.
Vartiainen, E.
Brand, S.-M.
Staessen, J.A.
Wang, T.J.
Burton, P.R.
Artigas, M.S.
Dong, Y.
Snieder, H.
Wang, X.
Zhu, H.
Lohman, K.K.
Rudock, M.E.
Heckbert, S.R.
Smith, N.L.
Wiggins, K.L.
Doumatey, A.
Shriner, D.
Veldre, G.
Viigimaa, M.
Kinra, S.
Prabhakaran, D.
Tripathy, V.
Langefeld, C.D.
Rosengren, A.
Thelle, D.S.
Corsi, A.M.
Singleton, A.
Forrester, T.
Hilton, G.
McKenzie, C.A.
Salako, T.
Iwai, N.
Kita, Y.
Ogihara, T.
Ohkubo, T.
Okamura, T.
Ueshima, H.
Umemura, S.
Eyheramendy, S.
Meitinger, T.
Wichmann, H.-E.
Cho, Y.S.
Kim, H.-L.
Lee, J.-Y.
Scott, J.
Sehmi, J.S.
Zhang, W.
Hedblad, B.
Nilsson, P.
Smith, G.D.
Wong, A.
Narisu, N.
Stančáková, A.
Raffel, L.J.
Yao, J.
Kathiresan, S.
O'Donnell, C.J.
Schwartz, S.M.
Arfan Ikram, M.
Longstreth Jr., W.T.
Mosley, T.H.
Seshadri, S.
Shrine, N.R.G.
Wain, L.V.
Morken, M.A.
Swift, A.J.
Laitinen, J.
Prokopenko, I.
Zitting, P.
Cooper, J.A.
Humphries, S.E.
Danesh, J.
Rasheed, A.
Goel, A.
Hamsten, A.
Watkins, H.
Bakker, S.J.L.
van Gilst, W.H.
Janipalli, C.S.
Radha Mani, K.
Yajnik, C.S.
Hofman, A.
Mattace-Raso, F.U.S.
Oostra, B.A.
Demirkan, A.
Isaacs, A.
Rivadeneira, F.
Lakatta, E.G.
Orru, M.
Scuteri, A.
Ala-Korpela, M.
Kangas, A.J.
Lyytikäinen, L.-P.
Soininen, P.
Tukiainen, T.
Würtz, P.
Twee-HeeOng, R.
Dörr, M.
Kroemer, H.K.
Völker, U.
Völzke, H.
Galan, P.
Hercberg, S.
Lathrop, M.
Zelenika, D.
Deloukas, P.
Mangino, M.
Spector, T.D.
Zhai, G.
Meschia, J.F.
Nalls, M.A.
Sharma, P.
Terzic, J.
Kranthi Kumar, M.V.
Denniff, M.
Zukowska-Szczechowska, E.
Wagenknecht, L.E.
Fowkes, F.G.R.
Charchar, F.J.
Schwarz, P.E.H.
Hayward, C.
Guo, X.
Rotimi, C.
Bots, M.L.
Brand, E.
Samani, N.J.
Polasek, O.
Talmud, P.J.
Nyberg, F.
Kuh, D.
Laan, M.
Hveem, K.
Palmer, L.J.
van der Schouw, Y.T.
Casas, J.P.
Mohlke, K.L.
Vineis, P.
Raitakari, O.
Ganesh, S.K.
Wong, T.Y. 
Shyong Tai, E.
Cooper, R.S.
Laakso, M.
Rao, D.C.
Harris, T.B.
Morris, R.W.
Dominiczak, A.F.
Kivimaki, M.
Marmot, M.G.
Miki, T.
Saleheen, D.
Chandak, G.R.
Coresh, J.
Navis, G.
Salomaa, V.
Han, B.-G.
Zhu, X.
Kooner, J.S.
Melander, O.
Ridker, P.M.
Bandinelli, S.
Gyllensten, U.B.
Wright, A.F.
Wilson, J.F.
Ferrucci, L.
Farrall, M.
Tuomilehto, J.
Pramstaller, P.P.
Elosua, R.
Soranzo, N.
Sijbrands, E.J.G.
Altshuler, D.
Loos, R.J.F.
Shuldiner, A.R.
Gieger, C.
Meneton, P.
Uitterlinden, A.G.
Wareham, N.J.
Gudnason, V.
Rotter, J.I.
Rettig, R.
Uda, M.
Strachan, D.P.
Witteman, J.C.M.
Hartikainen, A.-L.
Beckmann, J.S.
Boerwinkle, E.
Vasan, R.S.
Boehnke, M.
Larson, M.G.
Järvelin, M.-R.
Psaty, B.M.
Abecasis, G.R.
Chakravarti, A.
Elliott, P.
van Duijn, C.M.
Newton-Cheh, C.
Levy, D.
Caulfield, M.J.
Johnson, T.
Issue Date: 6-Oct-2011
Citation: Ehret, G.B., Munroe, P.B., Rice, K.M., Bochud, M., Johnson, A.D., Chasman, D.I., Smith, A.V., Tobin, M.D., Verwoert, G.C., Hwang, S.-J., Pihur, V., Vollenweider, P., O'Reilly, P.F., Amin, N., Bragg-Gresham, J.L., Teumer, A., Glazer, N.L., Launer, L., Zhao, J.H., Aulchenko, Y., Heath, S., Sober, S., Parsa, A., Luan, J., Arora, P., Dehghan, A., Zhang, F., Lucas, G., Hicks, A.A., Jackson, A.U., Peden, J.F., Tanaka, T., Wild, S.H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A.N., Fava, C., Chambers, J.C., Fox, E.R., Kumari, M., Go, M.J., van der Harst, P., Kao, W.H.L., Sjögren, M., Vinay, D.G., Alexander, M., Tabara, Y., Shaw-Hawkins, S., Whincup, P.H., Liu, Y., Shi, G., Kuusisto, J., Tayo, B., Seielstad, M., Sim, X., Hoang Nguyen, K.-D., Lehtimäki, T., Matullo, G., Wu, Y., Gaunt, T.R., Charlotte Onland-Moret, N., Cooper, M.N., Platou, C.G.P., Org, E., Hardy, R., Dahgam, S., Palmen, J., Vitart, V., Braund, P.S., Kuznetsova, T., Uiterwaal, C.S.P.M., Adeyemo, A., Palmas, W., Campbell, H., Ludwig, B., Tomaszewski, M., Tzoulaki, I., Palmer, N.D., Aspelund, T., Garcia, M., Chang, Y.-P.C., O'Connell, J.R., Steinle, N.I., Grobbee, D.E., Arking, D.E., Kardia, S.L., Morrison, A.C., Hernandez, D., Najjar, S., McArdle, W.L., Hadley, D., Brown, M.J., Connell, J.M., Hingorani, A.D., Day, I.N.M., Lawlor, D.A., Beilby, J.P., Lawrence, R.W., Clarke, R., Hopewell, J.C., Ongen, H., Dreisbach, A.W., Li, Y., Hunter Young, J., Bis, J.C., Kähönen, M., Viikari, J., Adair, L.S., Lee, N.R., Chen, M.-H., Olden, M., Pattaro, C., Bolton, J.A.H., Köttgen, A., Bergmann, S., Mooser, V., Chaturvedi, N., Frayling, T.M., Islam, M., Jafar, T.H., Erdmann, J., Kulkarni, S.R., Bornstein, S.R., Grässler, J., Groop, L., Voight, B.F., Kettunen, J., Howard, P., Taylor, A., Guarrera, S., Ricceri, F., Emilsson, V., Plump, A., Barroso, I., Khaw, K.-T., Weder, A.B., Hunt, S.C., Sun, Y.V., Bergman, R.N., Collins, F.S., Bonnycastle, L.L., Scott, L.J., Stringham, H.M., Peltonen, L., Perola, M., Vartiainen, E., Brand, S.-M., Staessen, J.A., Wang, T.J., Burton, P.R., Artigas, M.S., Dong, Y., Snieder, H., Wang, X., Zhu, H., Lohman, K.K., Rudock, M.E., Heckbert, S.R., Smith, N.L., Wiggins, K.L., Doumatey, A., Shriner, D., Veldre, G., Viigimaa, M., Kinra, S., Prabhakaran, D., Tripathy, V., Langefeld, C.D., Rosengren, A., Thelle, D.S., Corsi, A.M., Singleton, A., Forrester, T., Hilton, G., McKenzie, C.A., Salako, T., Iwai, N., Kita, Y., Ogihara, T., Ohkubo, T., Okamura, T., Ueshima, H., Umemura, S., Eyheramendy, S., Meitinger, T., Wichmann, H.-E., Cho, Y.S., Kim, H.-L., Lee, J.-Y., Scott, J., Sehmi, J.S., Zhang, W., Hedblad, B., Nilsson, P., Smith, G.D., Wong, A., Narisu, N., Stančáková, A., Raffel, L.J., Yao, J., Kathiresan, S., O'Donnell, C.J., Schwartz, S.M., Arfan Ikram, M., Longstreth Jr., W.T., Mosley, T.H., Seshadri, S., Shrine, N.R.G., Wain, L.V., Morken, M.A., Swift, A.J., Laitinen, J., Prokopenko, I., Zitting, P., Cooper, J.A., Humphries, S.E., Danesh, J., Rasheed, A., Goel, A., Hamsten, A., Watkins, H., Bakker, S.J.L., van Gilst, W.H., Janipalli, C.S., Radha Mani, K., Yajnik, C.S., Hofman, A., Mattace-Raso, F.U.S., Oostra, B.A., Demirkan, A., Isaacs, A., Rivadeneira, F., Lakatta, E.G., Orru, M., Scuteri, A., Ala-Korpela, M., Kangas, A.J., Lyytikäinen, L.-P., Soininen, P., Tukiainen, T., Würtz, P., Twee-HeeOng, R., Dörr, M., Kroemer, H.K., Völker, U., Völzke, H., Galan, P., Hercberg, S., Lathrop, M., Zelenika, D., Deloukas, P., Mangino, M., Spector, T.D., Zhai, G., Meschia, J.F., Nalls, M.A., Sharma, P., Terzic, J., Kranthi Kumar, M.V., Denniff, M., Zukowska-Szczechowska, E., Wagenknecht, L.E., Fowkes, F.G.R., Charchar, F.J., Schwarz, P.E.H., Hayward, C., Guo, X., Rotimi, C., Bots, M.L., Brand, E., Samani, N.J., Polasek, O., Talmud, P.J., Nyberg, F., Kuh, D., Laan, M., Hveem, K., Palmer, L.J., van der Schouw, Y.T., Casas, J.P., Mohlke, K.L., Vineis, P., Raitakari, O., Ganesh, S.K., Wong, T.Y., Shyong Tai, E., Cooper, R.S., Laakso, M., Rao, D.C., Harris, T.B., Morris, R.W., Dominiczak, A.F., Kivimaki, M., Marmot, M.G., Miki, T., Saleheen, D., Chandak, G.R., Coresh, J., Navis, G., Salomaa, V., Han, B.-G., Zhu, X., Kooner, J.S., Melander, O., Ridker, P.M., Bandinelli, S., Gyllensten, U.B., Wright, A.F., Wilson, J.F., Ferrucci, L., Farrall, M., Tuomilehto, J., Pramstaller, P.P., Elosua, R., Soranzo, N., Sijbrands, E.J.G., Altshuler, D., Loos, R.J.F., Shuldiner, A.R., Gieger, C., Meneton, P., Uitterlinden, A.G., Wareham, N.J., Gudnason, V., Rotter, J.I., Rettig, R., Uda, M., Strachan, D.P., Witteman, J.C.M., Hartikainen, A.-L., Beckmann, J.S., Boerwinkle, E., Vasan, R.S., Boehnke, M., Larson, M.G., Järvelin, M.-R., Psaty, B.M., Abecasis, G.R., Chakravarti, A., Elliott, P., van Duijn, C.M., Newton-Cheh, C., Levy, D., Caulfield, M.J., Johnson, T. (2011-10-06). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478 (7367) : 103-109. ScholarBank@NUS Repository. https://doi.org/10.1038/nature10405
Abstract: Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140mmg Hg systolic blood pressure ≥90mmg Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3 GUCY1B3, NPR3 C5orf23, ADM, FURIN FES, GOSR2, GNAS EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention. © 2011 Macmillan Publishers Limited. All rights reserved.
Source Title: Nature
URI: http://scholarbank.nus.edu.sg/handle/10635/108383
ISSN: 00280836
DOI: 10.1038/nature10405
Appears in Collections:Staff Publications

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