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Title: Evaluation of health outcomes in osteoarthritis patients after total knee replacement: A two-year follow-up
Authors: Xie, F.
Lo, N.-N.
Pullenayegum, E.M.
Tarride, J.-E.
O'Reilly, D.J.
Goeree, R.
Lee, H.-P. 
Issue Date: 19-Aug-2010
Source: Xie, F., Lo, N.-N., Pullenayegum, E.M., Tarride, J.-E., O'Reilly, D.J., Goeree, R., Lee, H.-P. (2010-08-19). Evaluation of health outcomes in osteoarthritis patients after total knee replacement: A two-year follow-up. Health and Quality of Life Outcomes 8 : -. ScholarBank@NUS Repository.
Abstract: Objectives: To quantify the improvement in health outcomes in patients after total knee replacement (TKR).Methods: This was a two-year non-randomized prospective observational study in knee osteoarthritis (OA) patients undergone TKR. Patients were interviewed one week before, six months after, and two years after surgery using a standardized questionnaire including the SF-36, the Oxford Knee Score (OKS), and the Knee Society Clinical Rating Scale (KSS). A generalized estimating equation (GEE) model was used to estimate the magnitudes of the changes with and without the adjustment of age, ethnicity, BMI, and years with OA.Results: A total of 298 (at baseline), 176 (at six-months), and 111 (at two-years) eligible patients were included in the analyses. All the scores changed significantly over time, with the exception of SF-36 social functioning, vitality, and mental health. With the adjustment of covariates, the magnitude of changes in these scores was similar to those without the adjustment.Conclusions: Both general and knee-specific physical functioning had been significantly improved after TKR, while other health domains have not been substantially improved after the surgery. © 2010 Xie et al; licensee BioMed Central Ltd.
Source Title: Health and Quality of Life Outcomes
ISSN: 14777525
DOI: 10.1186/1477-7525-8-87
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