Please use this identifier to cite or link to this item: https://doi.org/10.2337/dc10-2097
Title: Ethnicity modifies the relationships of insulin resistance, inflammation, and adiponectin with obesity in a multiethnic Asian population
Authors: Khoo, C.M.
Sairazi, S.
Taslim, S.
Gardner, D.
Wu, Y. 
Lee, J. 
Van Dam, R.M. 
Tai, E.S.
Issue Date: May-2011
Citation: Khoo, C.M., Sairazi, S., Taslim, S., Gardner, D., Wu, Y., Lee, J., Van Dam, R.M., Tai, E.S. (2011-05). Ethnicity modifies the relationships of insulin resistance, inflammation, and adiponectin with obesity in a multiethnic Asian population. Diabetes Care 34 (5) : 1120-1126. ScholarBank@NUS Repository. https://doi.org/10.2337/dc10-2097
Abstract: OBJECTIVE - The development of obesity-related metabolic disorders varies with ethnicity. We examined whether ethnicity modifies the relationship between BMI and three metabolic pathways (insulin resistance, inflammation, and adiponectin) that are involved in the pathogenesis of diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS - We analyzed data from 4,804 Chinese, Malay, and Asian-Indian residents of Singapore with complete data on insulin resistance (IR), C-reactive protein (CRP), and total adiponectin levels. Linear regression models with an interaction term ethnicity*BMI were used to evaluate whether ethnicity modifies the association between BMI and IR, CRP, and adiponectin. RESULTS - In both uni- and multivariate analyses, BMI was directly associated with IR and CRP and inversely with adiponectin across all ethnic groups. When compared with Chinese and Malays, Asian-Indians had higher IR and CRP and lower adiponectin levels. The associations between BMI and its metabolic pathways were significantly stronger in Chinese than in other ethnic groups. The increase in IR and CRP and the decrease in adiponectin for each unit increase in BMI were greater in Chinese than in other ethnic groups. The findings were similar when waist circumference was used in the analyses instead of BMI. CONCLUSIONS - The impact of BMI on IR, CRP, and adiponectin appears greater in Chinese as compared with other major Asian ethnic groups. This may partly explain the rapid increase in the prevalence of diabetes and CVD in Chinese populations and highlights the importance of weight management in Asian ethnic groups despite the apparently low levels of obesity. © 2011 by the American Diabetes Association.
Source Title: Diabetes Care
URI: http://scholarbank.nus.edu.sg/handle/10635/108373
ISSN: 01495992
DOI: 10.2337/dc10-2097
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

60
checked on Dec 10, 2018

WEB OF SCIENCETM
Citations

55
checked on Nov 26, 2018

Page view(s)

37
checked on Dec 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.