Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/108315
Title: Corticospinal tract degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging and fibre tractography study
Authors: Yin, H.
Cheng, S.H.T.
Zhang, J.
Ma, L.
Gao, Y.
Li, D.
Lim, C.C.T. 
Keywords: Amyltrophic lateral sclerosis
Diffusion-weighted imaging
Echo planar imaging
Fibre tractography
Magnetic resonance imaging
Issue Date: May-2008
Citation: Yin, H.,Cheng, S.H.T.,Zhang, J.,Ma, L.,Gao, Y.,Li, D.,Lim, C.C.T. (2008-05). Corticospinal tract degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging and fibre tractography study. Annals of the Academy of Medicine Singapore 37 (5) : 411-415. ScholarBank@NUS Repository.
Abstract: Introduction: Motor neuron damage and cortical spinal tract (CST) degeneration in amyotrophic lateral sclerosis (ALS) are difficult to visualise and quantify on conventional magnetic resonance imaging (MRI). Clinical Picture: We studied 8 ALS patients and 12 normal volunteers using diffusion tensor imaging (DTI) and fibre tractography using fibre assignment by continuous tracking (FACT) to study the fibres of the CST and the posterior thalamic radiation (PTR), a non-motor tract. Outcome: Fibre tractography was successfully performed in all normal volunteers and all patients except 1. The fibre bundles of the CST, but not the PTR, were significantly reduced (P
Source Title: Annals of the Academy of Medicine Singapore
URI: http://scholarbank.nus.edu.sg/handle/10635/108315
ISSN: 03044602
Appears in Collections:Staff Publications

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