Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels
Soria, B. Quesada, I. Ropero, A.B. Pertusa, J.A. Martín, F. Nada, A.
Quesada, I.
Ropero, A.B.
Pertusa, J.A.
Martín, F.
Nada, A.
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Abstract
Glucose and other nutrients regulate many aspects of pancreatic islet physiology. This includes not only insulin release, but also insulin synthesis and storage and other aspects of β-cell biology, including cell proliferation, apoptosis, differentiation, and gene expression. This implies that in addition to the well-described signals for insulin release, other intracellular signaling mechanisms are needed. Here we describe the role of global and local Ca 2+ signals in insulin release, the regulation of these signals by new membrane receptors, and the generation of nuclear Ca 2+ signals involved in gene expression. An integrated view of these pathways should improve the present description of the β-cell biology and provide new targets for novel drugs.
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Source Title
Diabetes
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Date
2004-02
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Conference Paper