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|Title:||Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels|
|Authors:||Soria, B. |
|Source:||Soria, B.,Quesada, I.,Ropero, A.B.,Pertusa, J.A.,Martín, F.,Nada, A. (2004-02). Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels. Diabetes 53 (SUPPL. 1) : S86-S91. ScholarBank@NUS Repository.|
|Abstract:||Glucose and other nutrients regulate many aspects of pancreatic islet physiology. This includes not only insulin release, but also insulin synthesis and storage and other aspects of β-cell biology, including cell proliferation, apoptosis, differentiation, and gene expression. This implies that in addition to the well-described signals for insulin release, other intracellular signaling mechanisms are needed. Here we describe the role of global and local Ca 2+ signals in insulin release, the regulation of these signals by new membrane receptors, and the generation of nuclear Ca 2+ signals involved in gene expression. An integrated view of these pathways should improve the present description of the β-cell biology and provide new targets for novel drugs.|
|Appears in Collections:||Staff Publications|
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